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 | Research: Ibuprofen Best for Treating Post-Avonex-Injection Side Effects |
 This study tried to compare ibuprofen, acetaminophen, and corticosteroids for the treatment of flu-like symptoms that accompany Interferone-beta-1a (Avonex) injections. The result was that there was no clear winner, but ibuprofen seemed to help the most with symptoms immediately following the injection.
"OBJECTIVE: To compare the efficacy of acetaminophen, ibuprofen, and prednisone in the treatment of interferon beta-1a (IFNbeta-1a) flu-like syndrome (FLS)...
CONCLUSIONS: No prophylactic treatment for flu-like syndrome seems to be superior to another in terms of overall well-being during the first month of IM IFNbeta-1a therapy. However, ibuprofen confers better control of symptoms immediately following IM IFNbeta-1a injection."
Click "read more" for the full abstract...
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Full Abstract Text
Neurology. 2004 Aug 10;63(3):525-8.
Corticosteroids, ibuprofen, and acetaminophen for IFNbeta-1a flu symptoms in MS: a randomized trial.
Rio J, Nos C, Bonaventura I, Arroyo R, Genis D, Sureda B, Ara JR, Brieva L, Martin J, Saiz A, Sanchez Lopez F, Prieto JM, Roquer J, Dorado JF, Montalban X.
Centres H. Vall d'Hebron, Barcelona, Spain. jrio@vhebron.net
OBJECTIVE: To compare the efficacy of acetaminophen, ibuprofen, and prednisone in the treatment of interferon beta-1a (IFNbeta-1a) flu-like syndrome (FLS). METHODS: Patients with relapsing-remitting multiple sclerosis initiating treatment with IM IFNbeta-1a were randomized in a multicenter, randomized, double-blind, controlled trial to receive acetaminophen 500 mg before and 6 and 12 hours after each injection, ibuprofen 400 mg before and 6 and 12 hours after each injection, or prednisone 60 mg daily for 1 week, plus tapering. Patients were instructed to keep a daily diary of fever severity, myalgia, chills, headache, and asthenia for 27 days. The sum of the scores of individual symptoms was used to obtain a daily FLS index. The primary outcome was the FLS index area under the curve (AUC) corrected by the number of measurement days. RESULTS: Eighty-four patients were randomized at 11 hospitals: acetaminophen (n = 28), ibuprofen (n = 28), and corticosteroids (n = 28). No differences were detected between treatments in the mean AUC of the FLS index. With limitation of the analysis to the days of IM IFNbeta-1a injection, differences favoring ibuprofen were observed in the mean FLS index (p = 0.0007). CONCLUSIONS: No prophylactic treatment for flu-like syndrome seems to be superior to another in terms of overall well-being during the first month of IM IFNbeta-1a therapy. However, ibuprofen confers better control of symptoms immediately following IM IFNbeta-1a injection.
PMID: 15304586 [PubMed - in process]
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Re: Ibuprofen Best for Treating Post-Avonex-Injection Side Effects (Score: 1)
by zpop52 on Tuesday, October 19 @ 17:44:59 EDT
(User Info | Send a Message | Journal) | I found IBU to be more helpful after ACCIDENTLY
taking instead of Tylenol. Whoops, but the generic bottles looked the same, and I have continued with the IBU for the past two years or so. My Neuro. just shrugged when I told him. So I have happily continued! It is interesting to see that someone has studied the "accident". |
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