An useful new pair of studies in the journal Neurology show that the sleep disorder drug called Provigil (modafinil) is not helpful to MS patients suffering from fatigue, while the common pain-reliever aspirin might be.
While two earlier pilot studies had shown modest positive benefit from Provigil, this 56-person study showed the effect on fatigue to be indistinguishable from placebo. Meanwhile, a 30-person trial showed that aspirin did reduce fatigue compared to placebo.
Drs. Steven R. Schwid of the University of Rochester, New York, and T. Jock Murray of Dalhousie University in Halifax, Nova Scotia, observe that "until we make progress in distinguishing fatigue from other MS symptoms, in identifying its mechanisms and in measuring it accurately, we will not make substantial progress in treating this disabling symptom."
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