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 | Provigil Ineffective for MS Fatigue; Aspirin Might Help |
An useful new pair of studies in the journal Neurology show that the sleep disorder drug called Provigil (modafinil) is not helpful to MS patients suffering from fatigue, while the common pain-reliever aspirin might be.
While two earlier pilot studies had shown modest positive benefit from Provigil, this 56-person study showed the effect on fatigue to be indistinguishable from placebo. Meanwhile, a 30-person trial showed that aspirin did reduce fatigue compared to placebo.
Drs. Steven R. Schwid of the University of Rochester, New York, and T. Jock Murray of Dalhousie University in Halifax, Nova Scotia, observe that "until we make progress in distinguishing fatigue from other MS symptoms, in identifying its mechanisms and in measuring it accurately, we will not make substantial progress in treating this disabling symptom."
Click for a link to the source articles...
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Posted by Administrator on Saturday, April 23 @ 02:24:28 EDT (3895 reads)
(Read More... | 1079 bytes more | Score: 3)
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 | Teaching MS Patients to Save Energy Curbs Fatigue |
A rather obvious, but still interesting finding on fatigue. It seems that energy conservation strategies, particularly the one outlined below where a patient pretends they have a "bank" of energy and can only withdraw so much, have a significant beneficial impact on fatigue.
"People with multiple sclerosis (MS) often suffer extreme fatigue, but teaching them how to conserve energy helps combat the problem, according to a new study...
"We use a banking analogy," Mathiowetz explained. "You have X amount of money to work with - just like you have X amount of energy to work with. Just like in budgeting money, MS patients can budget their energy."
In the study, participants ... experienced a significant reduction in fatigue while taking the course with continued improvement afterwards.
Click "read more" for the full story...
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Posted by Administrator on Friday, October 08 @ 02:25:52 EDT (1932 reads)
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 | Research: Copaxone Better at Relieving Fatigue than Interferons |
This study shows that Copaxone improves fatigue symptoms better than the Interferon therapies...
"OBJECTIVE: To assess the effects of glatiramer acetate and beta interferon on fatigue in multiple sclerosis... CONCLUSIONS: The odds of reduced multiple sclerosis fatigue were around twice as great with glatiramer acetate treatment as with beta interferon. Confirmation of this result is required."
Click "read more" for the full abstract
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Posted by Administrator on Friday, August 06 @ 03:29:09 EDT (1969 reads)
(Read More... | 2466 bytes more | Research | Score: 5)
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 | Research: Yoga Helps Treat MS Fatigue |
 We love stories like this where a readily-available, low-cost therapy is critically examined for its use in multiple sclerosis. In this study, researchers found that Yoga helped fatigue associated with multiple sclerosis, but unfortunately did nothing for cognition or alertness.
"PORTLAND, Ore. -- Just six months of yoga significantly reduces fatigue in people with multiple sclerosis, but it has no effect on alertness and cognitive function, says a new Oregon Health & Science University study. The study, published June 8 in the journal Neurology, found that yoga is as good as a traditional aerobic exercise program in improving measures of fatigue, a common and potentially disabling symptom of MS. It was the first randomized, controlled trial of yoga in people with MS...
The MS study was not designed to determine the impact of yoga on the disease itself, said the study's lead author, Barry Oken, M.D., professor of neurology and behavioral neuroscience in the OHSU School of Medicine. Rather, it was intended to determine the effect of yoga and aerobic exercise on cognitive function, fatigue, mood and quality of life among people with MS.
'There are some claims out there that yoga helps MS itself, that it can decrease the number of lesions' in the brain caused by MS, said Oken, director of the Oregon Center for Complementary and Alternative Medicine in Neurological Disorders (ORCCAMIND) at OHSU. 'I'm not sure that that's not the case, because stress may have an impact on MS. But that was not what we were trying to show.'
Click "read more" for the full article...
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Posted by Administrator on Thursday, June 10 @ 03:40:56 EDT (1877 reads)
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 | Research: The Relationship of Sleep Disturbances and Fatigue in Multiple Sclerosis. |
 This study is the first to look at the correlation of fatigue and sleep disturbance in people with multiple sclerosis. It has a fairly sad result: people suffering from fatigure most often suffer from sleep disturbances. Which seems to us that it would create a vicious cycle of exhaustion during the day followed by non-restful sleep that night, followed by exhaustion during the day, ad nauseum
"BACKGROUND: Fatigue is experienced by most patients with multiple sclerosis (MS) and often is profoundly debilitating. No large-scale studies to our knowledge have examined circadian rhythm abnormalities in MS patients or the relationship of fatigue to circadian rhythms...
CONCLUSION: There is a significant correlation between fatigue in MS patients and disrupted sleep or abnormal sleep cycles."
Click "read more" for the full abstract...
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Posted by Administrator on Sunday, April 25 @ 16:29:08 EDT (1971 reads)
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 | Research: Treatment of Fatigue |
shayk writes "The Journal of Neurological Science (2004 Mar 15) reports on research comparing acetyl l-carnitine (ALCAR) and amantadine for the treatment of fatigue in MS.
Researchers at the Department of Neurological Sciences at the University of Rome conducted a pilot, randomized, double-blind crossover trial involving 36 MS patients who presented with fatigue. The abstract concludes: "The results of this study show that ALCAR is better tolerated and more effective than amantadine for the treatment of MS-related fatigue." The trial included treatment with amantadine (100 mg twice daily) or ALCAR (1 g twice daily.) Six patients (5 on amantadine and 1 on ALCAR) withdrew because of adverse reactions.
For complete information, please refer to: J Neurol Sci 2004 Mar 15;218(1-2):103-8. Comparison of the effects of acetyl l-carnitine and amantadine for the treatment of fatigue in multiple sclerosis: results of a pilot, randomized, double-blind, crossover trial. Tomassini V, et al "
Note: Thanks to Shayk for submitting this story! It is much appreciated!
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Posted by Administrator on Monday, February 23 @ 15:30:21 EST (1766 reads)
(Read More... | Research | Score: 5)
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 | Research: MS Fatigue Related to Nerve Damage in Brain |
 This study conjectures that the fatigue experiencec by most MS'ers is a result of overall nerve damage in the brain.
"Extensive nerve fiber damage in the brains of patients with multiple sclerosis (MS) is associated with the debilitating fatigue associated with the disease, according to an article in the February issue of The Archives of Neurology, one of the JAMA/Archives journals.
Our observations, combined with those of others, suggest that widespread axonal dysfunction is associated with fatigue in MS," the authors write. "It may be hypothesized that diffuse white matter [brain] disease translates into an increase in the central nervous system effort required by a patient with MS to perform the same activity as compared with a disease-free subject, with resultant fatigue."
Click "read more" for the full article...
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Posted by Administrator on Tuesday, February 17 @ 00:35:41 EST (1826 reads)
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 | Fatigue and Multiple Sclerosis |
Short blurb released by Harvard Med:
"If you have multiple sclerosis, you may be experiencing disabling fatigue, which is a common symptom.
Harvard Medical School offers these fatigue-relieving tips:
- Exercise regularly. This can improve your cardiovascular fitness, muscle strength, and help you feel more awake.
- During the warm months, exercise early in the morning or in the late evening, when it's coolest.
- A low-fat diet rich in whole grains and fresh fruit and vegetables will help keep your energy level up.
- Don't be shy to ask for help when you need it.
Speak to your doctor about medication that may provide some relief. "
- (HealthDayNews)
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Posted by Administrator on Sunday, February 08 @ 02:11:09 EST (1270 reads)
(Read More... | Score: 3)
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