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This Is MS: Blood-Brain Barrier (BBB)

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Research: Interferon-Beta Treatment Improves Blood-Brain Barrier

Blood-Brain Barrier (BBB)

The commonly held belief is that Interferon-Beta (such as Avonex, Rebif, Betaseron) achieves its beneficial effect on MS progress via its anti-inflammatory properties. This study, however, demonstrates that Interferon-Beta also improves the integrity of the Blood-Brain-Barrier (BBB)-- which generally breaks down in MS patients, allowing increasing amounts of undesirable substances to reach the brain. This strengthening of the BBB might be a contributing factor (if not THE factor?) to Interferon Beta's beneficial effects. Note that this study is in vitro (outside a living organism-- a petri dish experiment), so it does not necessarily mean it works the same in people.

"Multiple sclerosis (MS) is accompanied by a breakdown of the blood-brain barrier (BBB) leading to edema formation and aggravation of the disease...

Taken together, our data demonstrate a direct stabilizing effect of IFN-beta on BBB cerebral endothelial cells in vitro that might significantly contribute to the beneficial effects of IFN-beta treatment in MS in vivo."

Click "read more" for the full abstract...

Posted by Administrator on Friday, August 06 @ 02:07:34 EDT (1863 reads)
(Read More... | 2863 bytes more | Research | Score: 5)

Research: Interferon Beta 1b (Betaseron) Might Work by Plugging the Blood-Brain Barrier

Blood-Brain Barrier (BBB)

Very interesting new research that shows that Inteferon beta 1b (available in Betaseron) might work by preventing leukocytes (white blood cells) from crossing the blood brain barrier.

"Adhesion molecules (AMs) are believed to regulate the transmigration of blood leukocytes across the blood-brain barrier (BBB), which is an essential step in the pathogenesis of multiple sclerosis (MS)...

The expression levels of cell surface bound AMs on blood MNC remained stable during treatment. Untreated MS patients, however, showed a continuous decrease in the expression of cell surface bound AM expression over 18 months. Stabilisation of the expression of cell surface bound AMs on blood MNC may indicate the beneficial effects of IFN-beta(1b) therapy in MS patients."

PMID: 15083294 [PubMed - in process]

Click "read more" for the full abstract...

Posted by Administrator on Saturday, April 17 @ 15:22:32 EDT (1360 reads)
(Read More... | 3011 bytes more | Research | Score: 4)

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