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This Is MS: Minocycline

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 Research: Minocycline Downregulates T-Cell Activity

MinocyclineMinocycline is a tetracycline-class antibiotic that has shown some promise in treating multiple sclerosis. In fact, a trial is currently underway examining the efficacy of minocycline combined with Copaxone.

One of the main questions on the table when looking at the possible efficacy of an antibiotic for the treatment of MS is "how exactly does it help MS?" If it helps via its antibiotic activity, then that points to a (revolutionary) new view of MS as a disease caused or exacerbated by a bacterial pathogen. If however, it works in another fashion, then it speaks to the more accepted model of MS as an auto-immune inflammatory condition.

All that being said, this new study supports the latter explanation. It shows that minocylcine actually has the effect of lowering the activity of microglial cells (microglial cells are the immune system cells of the central nervous system), as had been seen in previous research, but also downregulates the activity of the "killer" T cells (immune system cells that are specifically programmed to kill a certain other type of cell).

Perhaps this is the pathway in which minocycline holds promise for MS... as always, no definitive answers YET in our quest to end this disease, but plenty of well-formed puzzle pieces.

"These results demonstrate that the mechanism of action of minocycline involves not only microglia but also T cells and their subsequent activation of microglia. The capacity of minocycline to down-regulate CD40L on T cells may provide a new means to target the CD40-CD40L pathway, which regulates several inflammatory processes."

Click "read more" for the full abstract....

Posted by Administrator on Sunday, July 24 @ 15:22:51 EDT (3073 reads)
(Read More... | 3846 bytes more | Research | Score: 4.66)

 News: Minocycline (oral antibiotic) shows Promise for MS

Minocycline

Minocycline is an oral antibiotic that is now showing great promise as a possible MS therapy that is easy to administer, affordable, and most important-- potentially effective. Along with the below article, there are a number of posts about minocycline in the Forums section of our site; do your research and while this research is very early, have hope that a readily-available drug could be very useful for MS.

"What makes minocycline even more exciting is that it is taken orally, eliminating the need for injections. And it costs only $80 a month, instead of thousands of dollars a month for other MS drugs.

The Calgary researchers made their findings after following 10 patients with the most common type of MS, called "relapsing-remitting." The disease brings on attacks in patients through lesions in the brain or spinal tissues.

The researchers found that minocycline substantially reduced the activity of the lesions by blocking the tissue from developing."

Click "read more" for the full article...


Posted by Administrator on Wednesday, June 02 @ 02:07:38 EDT (3530 reads)
(Read More... | 3910 bytes more | News | Score: 4.8)


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