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 Provigil Ineffective for MS Fatigue; Aspirin Might Help

FatigueAn useful new pair of studies in the journal Neurology show that the sleep disorder drug called Provigil (modafinil) is not helpful to MS patients suffering from fatigue, while the common pain-reliever aspirin might be.

While two earlier pilot studies had shown modest positive benefit from Provigil, this 56-person study showed the effect on fatigue to be indistinguishable from placebo. Meanwhile, a 30-person trial showed that aspirin did reduce fatigue compared to placebo.

Drs. Steven R. Schwid of the University of Rochester, New York, and T. Jock Murray of Dalhousie University in Halifax, Nova Scotia, observe that "until we make progress in distinguishing fatigue from other MS symptoms, in identifying its mechanisms and in measuring it accurately, we will not make substantial progress in treating this disabling symptom."

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Provigil Ineffective for MS Fatigue; Aspirin Might Help


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Re: Provigil Ineffective for MS Fatigue; Aspirin Might Help (Score: 1)
by Outlawbiker (Badges@Wedontneednostinkingbadges.com) on Saturday, April 23 @ 13:00:09 CDT
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I don''t believe that for a second!!!

It was like night and day for me the very first dose I took! That was back in 2001 and I''ve only needed to increase the dosage from 100 mg QD to 100 mg BID I''d never get out of bed without it.

Wish I could have accessed the Neurology link with this article but I''m not paying for it.



Re: Provigil Ineffective for MS Fatigue; Aspirin Might Help (Score: 1)
by kimi001 on Thursday, May 31 @ 11:25:38 CDT
(User Info | Send a Message) http://www.myspace.com/kimi001
I don''t believe Aspirin could possibly help fatigue. I have been taking Provigil for apprx a year and at times it works great, but other times I can take 1 then another and it will not help at all. It''s kinda like the lottery. I take one and cross my fingers to stay awake.



Re: Provigil Ineffective for MS Fatigue; Aspirin Might Help (Score: 1)
by Lovermont on Wednesday, August 15 @ 10:21:15 CDT
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Interesting how everyone is different. Provigil is ineffective for me - doesn''t work at all. I wish it did because my neurologist didn''t bat an eyelash in prescribing it to me. However he is very recultant to prescribe a stimulant and hasn''t even though I can barely take care of myself and I''m losing weight because I can''t shop or cook for myself.






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