For those interested in the hormonal link of MS is the following new study, which shows 17-beta estradiol provents the myelin-producing oligodendrocytes from dying. Be forewarned that much of this will be gibberish without a medical degree.
"During pregnancy, changes in circulating levels of hormones, including estrogens, correlates with a significant decrease in the relapse incidence in women with Multiple Sclerosis (MS)...
These results strongly suggest that 17beta-estradiol protects oligodendrocytes against SIN-1 mediated cytotoxicity through the activation of the estrogen receptors and provides new insights into the roles of the estrogen signaling pathways in myelin forming cells that are lost in demyelinating disorders."
Click "read more" for the full abstract
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Full Article Text
17beta-estradiol protects oligodendrocytes from cytotoxicity induced cell death.
Takao T, Flint N, Lee L, Ying X, Merrill J, Chandross KJ.
Second Department of Internal Medicine, Kochi Medical School, Nankoku, Japan.
During pregnancy, changes in circulating levels of hormones, including estrogens, correlates with a significant decrease in the relapse incidence in women with Multiple Sclerosis (MS). In the present study, we demonstrate that both primary and cell line cultures of rat oligodendrocytes express the estrogen receptor (ER)-alpha and ERbeta estrogen receptors in the cytosol and nucleus, and that nuclear compartmentalization becomes more pronounced as the cells mature. Moreover, 17beta-estradiol significantly decreases the cytotoxic effects of the peroxynitrite generator 3-(4-morpholinyl)-sydnonimine (SIN-1) in both immature and mature oligodendrocytes in a dose dependent manner. This protective mechanism requires pretreatment with 17beta-estradiol and is blocked by ICI 182,780, a selective ERalpha/ERbeta antagonist. These results strongly suggest that 17beta-estradiol protects oligodendrocytes against SIN-1 mediated cytotoxicity through the activation of the estrogen receptors and provides new insights into the roles of the estrogen signaling pathways in myelin forming cells that are lost in demyelinating disorders.
PMID: 15086523 [PubMed - in processJ
Neurochem. 2004 May;89(3):660-73.
Original article can be found here
