schnittke wrote:Thanks for the helpful info! You made the statement "I suspect that Mino will soon become the standard treatment for MS" and I am curious as to
why you feel that way. Simply interested and am in no way trying to
There have been 4 long term trials (6 months to two years) of Minocycline and MS, one in Germany, one in the USA and two in Canada. of the 40 people involved, more than 30 had complete resolution of MRI visible lesions and most also reported dramatic improvements in all aspects of the disease. In one year follow ups, virtually no new lesions developed. No other drug that I know of has been able to produce these kinds of results, and Minocycline is safe and quite inexpensive. Those who did not show improvement, almost universally dropped out of the studies, primarily due to GI upset.
Over 6.5 million people have been on Minocycline for an average of 9 months in the UK alone, and millions more in North America and Europe, as it is the standard treatment for adult acne, so it has been proven safe, especially as many of these people also had MS, and AFAIK there are no case reports of MS getting worse due to Minocycline. A large scale, long term trial is underway now (AFAIK) in Canada, but the results will not be known for another two years. However, the results of the long term, small scale studies, have been so compelling, that I find it hard to believe that more MS sufferers are not using Minocycline.
There is abundant evidence that a variety of bacterial/spirochetal diseases either cause MS directly, or trigger an autoimmune response that initiates the disease. Lyme Disease and MS have an almost perfect overlap when cases are plotted on maps, for example, and in Canada the medical community is claiming that Lyme Disease (LD) is virtually non existent, when other geographical areas at the same latitude show a rate of LD 10 to 300 times higher. Yet Canada has one of the highest MS rates in the world.
Minocycline is effective against most of the suspected bacterial/spirochetal diseases and has been proven to protect the CNS even when no pathogen is present, so it is a win-win drug: It will kill the disease, but also protect the CNS when no infection is present. Minocycline can also inhibit some types of viral reproduction as well, and has been proven effective against West Nile, for example.
There is a debate in the medical community over the efficacy of long term antibiotic treatment for LD, but the amazing thing is that when MS is treated like drug resistant type of LD, with long term antibiotics, most MS sufferers show a dramatic improvement. If you cannot tolerate minocycline, then Doxycyline and (maybe) tetracycline may also be effective.
But wait...there's more!
Minocycline has been shown to be effective against RA, and also against depression! It also seems to fight the brain fog that is a feature of late stage LD and MS.
The evidence for Minocycline is compelling IMHO.
I should add that if you do happen to have infection that is triggering your MS, that you may feel worse before you get better. This may be due to the Jarisch-Herxheimer reaction: