Hello to all,
more than 4 years without new posts in this thread: no interest in the double-blind study done in CIS patients in Canada since ca. 2008 (any more)?http://mssociety.ca/Alberta/pdf/MS_Conn ... sDec07.pdf
The preliminary results have been reported in the ECTRIMS Conference 2015 at Barcelona / Spain by Prof. Luanne Metz of Calgary on Oct. 10th - without any notice here on TIMS?
The first news report was by a German medical news paper just 2 months ago:http://www.aerztezeitung.de/extras/druc ... pid=887306
(I stirred a lot of discussion in Germany in advance already, because I knew Prof. Metz would come to Barcelona and report the results - which would be very favorable, I was sure...)
But almost no coverage in English? Very strange...http://www.medpagetoday.com/clinical-co ... osis/54038http://www.emaxhealth.com/1275/generic- ... -sclerosisI guess this study could open up a new eara in MS: stop the disease even before it is diagnosed.
I myself have taken doxycycline instead for 20 years by now (most of the time in short "pulses" once per month as a precaution against relapses) - with good arguments in favor of doxy over minocycine. There were quite a few drop-outs in this study (and at least one other 200 mg minocycline study before from Calgary): minocycline at 2x 100 mg per day is not very well tolerated, which is not the case with doxy.
See this study comparing the two over ?18 months (for another indication, not MS):http://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18212521/
Doxycycline obviously is highly effective in MS even at 100 mg per day:http://archneur.jamanetwork.com/article ... ol.2007.41http://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24250865/
Now we have to wait for the regular publication of the full results from Calgary.
I suppose that the compliance in the study in Canada was questionable (also the blinding...): the results possibly would have been even better if doxycycline had been used...
Doxycycliine has practically no risk (definitely lower than ASS, paracetamol etc.), if you avoid full sun.
From what I know a short course of 2-3 weeks (200-300 mg per day) will be effective too (that is: the main effect is within the first days or few weeks, like in the therapy of an ongoing infection):
This infection is not with Cpn (which is a respiratory pathogen, never demonstrated histopathologically in MS lesions, as far as I know), but a spirochetal infection - similar to late neurosyphilis (which is treated with penicillin or doxycycline).
I have to inform on the early evidence from Germany (in German) some other day, but for the time being these two sources in English, more than 4 decades apart, as a hint:http://www.ncbi.nlm.nih.gov/pmc/articles/pmid/13608292/http://www.ncbi.nlm.nih.gov/pubmed/11787831
Spread the good news: A world without MS becomes a realistic vision,