Vanderbilt Article in Press

A forum for the discussion of antibiotics as a potential therapy for MS

Postby SarahLonglands » Thu Jun 23, 2005 3:35 am

Hello Jim,

A question from me now, relevant more to people on your side of the Atlantic: You say that your doctor was quite willing to prescribe 'the whole thing', seeming to imply that was David's regime. Does this mean roxithromycin as well? I was under the impression that it just was not available in the USA or Canada, but maybe it is only like it is here: not on the national lists but may be prescribed if you can persuade a doctor to do so?

Also I am going to ask David about Tinidazole, because metronidizole still makes me feel very horrible. I found this on the internet:

http://www.mdbrowse.com/Druginf/T/tinidazole.htm

Action

Highly active against Entamoeba histolytica. Trichomonas vaginalis, Giardia lambila and anaerobic bacteria such as gardnerella vaginalis, Clostridium species. Tinidazole is converted to the active metabolite by reduction at the 5-nitro position. The active metabolite causes DNA damage in pathogens.



Interactions

Tinidazole increases the risk of bleeding when combined with anticoagulants. When the drug is taken along with alcohol, disufiram like reaction occurs. Enzyme inducers ( phenobarbitone, rifampicin ) and cimetidine can reduce the metabolism of tinidazole.




Adverse Effect & Precautions

Nausea, epigastric discomfort, metallic taste, furred tongue, neuropathy, skin rash, uriticaria, angioedema, leucopenia, seizures on prolonged dyscrasias.

Sarah
SarahLonglands
Family Elder
 
Posts: 2105
Joined: Thu Jun 17, 2004 3:00 pm
Location: Bedfordshire UK

Advertisement

Cpn regime comments

Postby Jimk » Thu Jun 23, 2005 5:42 am

I'm not sure if this is wandering too far afield from the discussion here, this string being on Vanderbilt study, but to followup on some questions:
I'm taking 500 mg twice a day of inositol hexanicotinate (no flush niacin). I tried niacinamide, but it didn't seem to have the abx boosting effect this has. This one seems to increase the impact of the abx I'm taking (doxy and zithro) which niacinamide didn't. I have tried niacin, but didn't like the flushing effect. Stratton seems to indicate that any of the niacin molecules are anti Cpn, and it seemed a better alternative to INH which has more toxicity.

Sara- I have only done one round of the Tini, but have much less nausea and don't feel so sick and toxic on it. I had grown increasingly sensitized to the Flagyl, where even one dose made me profoundly sick. I was going to try Macrobid, as Stratton found it in vitro to kill the cryptic form of Cpn (despite it being known only as a mediocre urinary abx) if the Tini didn't work. I'm not sure yet if the 500 mg twice a day of the Tini is quite enough yet. Next pulse will tell. But I could tolerate a 5 day pulse fine, where before I could only do about 3 days.
User avatar
Jimk
Family Member
 
Posts: 69
Joined: Fri Jun 17, 2005 3:00 pm
Location: Ohio, USA

Re: Cpn regime comments

Postby Daunted » Sat Jul 09, 2005 1:09 pm

What dose of Inositol Hexanicotinate are you taking?

I see safe ranges from 500mg to 2000mg; it seems pretty clear that 3000mg and above is associated with hepatoxicity.
On Vanderbilt Antibiotic Protocol since January
User avatar
Daunted
Family Elder
 
Posts: 271
Joined: Sun May 30, 2004 3:00 pm
Location: University Town, USA

Tini & Inositol Hexanicotinate

Postby Jimk » Sat Jul 09, 2005 1:30 pm

Sarah-
I'm on my second round of Tini. Tolerate it much better and it seems to do the trick! 500mg twice a day as David had suggested.

Daunted-
I'm just doing 100mg two or three times a day of the Inositol Hexanicotinate. I wrote Charles Stratton to see what he recommended and never heard back from him. I'll try again. Seems to potentiate the abx as I get some added herx with it than without.

Are you doing the amoxi and zithro? I'm wondering if this might be a good time for me to alternate a month on amoxi/zithro with my current doxy/zithro.
User avatar
Jimk
Family Member
 
Posts: 69
Joined: Fri Jun 17, 2005 3:00 pm
Location: Ohio, USA

Re: Tini & Inositol Hexanicotinate

Postby Daunted » Sat Jul 09, 2005 2:11 pm

Jimk wrote:Sarah-
I'm on my second round of Tini. Tolerate it much better and it seems to do the trick! 500mg twice a day as David had suggested.

Daunted-
I'm just doing 100mg two or three times a day of the Inositol Hexanicotinate. I wrote Charles Stratton to see what he recommended and never heard back from him. I'll try again. Seems to potentiate the abx as I get some added herx with it than without.

Are you doing the amoxi and zithro? I'm wondering if this might be a good time for me to alternate a month on amoxi/zithro with my current doxy/zithro.


Well I'm doing 1500mg of Inositol Hexanicotinate a day at present and I get a rush off of that, that's for sure. I would love any guidance, though, although I sort of decided 1500mg was the upper safe range after my reading.

I'm doing Amoxicillin, Zithromax, Doxycycline, and Flagyl- and I'm doing a mega-pulse of Flagyl, I think I'm 15 or 16 days in. I've stayed on the Amoxcillin continually.

But you don't swap out one antibiotic for the other (I found what you said a bit confusing), you just add amoxicillin to take care of the elementary bodies.
On Vanderbilt Antibiotic Protocol since January
User avatar
Daunted
Family Elder
 
Posts: 271
Joined: Sun May 30, 2004 3:00 pm
Location: University Town, USA

Sorry for the error

Postby Jimk » Sat Jul 09, 2005 5:32 pm

Daunted-
I'm in brain fog today... too long at the computor::oops:
I had already said in an earlier post that I'm doing 500mg of the no flush niacin twice a day, so total, obviously, of 1000mg. Seems enough to me.

I don't know where the "100mg" came from.

I know you've sent me materials on the amoxi dose you are using, but could you remind me here, or through message?
Thanks :lol:
User avatar
Jimk
Family Member
 
Posts: 69
Joined: Fri Jun 17, 2005 3:00 pm
Location: Ohio, USA

causes of chronic disease

Postby gibbledygook » Sun Jul 10, 2005 4:21 am

I'm wondering if antibiotics might be of use to a friend suffering from MMN (multifocal motor neuropathy). Apparently a study of people vaccinated/infected with borrelia burgdorferi showed one person developing MMN.
Neurological syndromes that follow vaccination or infection are often attributed to autoimmune mechanisms. We report six patients who developed neuropathy or cognitive impairment, within several days to 2 months, following vaccination with the OspA antigen of Borrelia burgdorferi. Two of the patients developed cognitive impairment, one chronic inflammatory demyelinating polyneuropathy (CIDP), one multifocal motor neuropathy, one both cognitive impairment and CIDP, and one cognitive impairment and sensory axonal neuropathy. The patients with cognitive impairment had T2 hyperintense white matter lesions on magnetic resonance imaging. The similarity between the neurological sequelae observed in the OspA-vaccinated patients and those with chronic Lyme disease suggests a possible role for immune mechanisms in some of the manifestations of chronic Lyme disease that are resistant to antibiotic treatment.
I'm afraid I pinched this wholly from PubMed on this link <shortened url>. Hope I am not causing royalty problems. Anyway my friend has not responded to any treatments so far. Maybe antibiotics to kill lyme might help. Any views?
User avatar
gibbledygook
Family Elder
 
Posts: 1412
Joined: Mon Feb 14, 2005 4:00 pm
Location: London

Postby SarahLonglands » Sun Jul 10, 2005 5:22 am

Alex, having read up a little bit on it I think it would be hopefully more than worth a try. Would your friend be willing to come to see David? To take a full medical history would be wise rather than just self dosing.

You can pinch as many abstracts from pub med as you wish: it is only the full text papers that you need to be wary of. :?

Sarah
SarahLonglands
Family Elder
 
Posts: 2105
Joined: Thu Jun 17, 2004 3:00 pm
Location: Bedfordshire UK

Worth a shot

Postby gibbledygook » Sun Jul 10, 2005 5:46 am

I shall encourage her to visit Bedford! At least antibiotics might not harm her but who knows. Thanks Anecdote!
User avatar
gibbledygook
Family Elder
 
Posts: 1412
Joined: Mon Feb 14, 2005 4:00 pm
Location: London

Previous

Return to Antibiotics

 


  • Related topics
    Replies
    Views
    Last post

Who is online

Users browsing this forum: tradecookiejar


Contact us | Terms of Service