I haven't taken minocycline myself, but Stratton noted to me that he considers it to have more tissue penetration than some other abx, and so I would expect it to be more potent as a starter than others, such as doxy or zith. All the Cpn protocols, Stratton, Wheldon, start quite slowly and ramp up carefully as the impact of endotoxin, porphyria, and cytokine reactions can be quite strong if your load is high, or the locus of the infection is neuro.
While mino supposedly is liked by MS docs because it is immunomodulatory (and so may have calming effect to the autoimmune problems as well as lower your cytokine reactions to bacterial die-off) by anecdotal reports people seem to have pretty strong reactions to it's effect.
So, go slow! Gotta breathe!
Wheldon Protocol Since Nov. 2004