ABX, W/ Rebif

A forum for the discussion of antibiotics as a potential therapy for MS

ABX, W/ Rebif

Postby viper498 » Wed Oct 12, 2005 7:09 am

Does anyone have any one have any casual recommendations as to what ABX to take, how much to take, and the frequency? I noticed that the trials running now only involve mino, or doxy, but I noticed several of you all posting that you are taking both? or other combo's? Why, what is the mode of action? As long as you are receiving the MMP's, isn't that what matters? Paratek is developing a non-antibiotic tetracycline, when that comes out will those of you taking combos switch to that only?
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Postby Anecdote » Wed Oct 12, 2005 7:40 am

Paratek is developing a non-antibiotic tetracycline, when that comes out will those of you taking combos switch to that only?

No, because we are mostly taking the antibiotics because that is what they are, and we are using the theory that MS is caused by a CPn infection. Read this written by my husband, a consultant medical microbiologist:

http://www.davidwheldon.co.uk/ms-treatment.html

Also take a look at most of the postings in the Regimens section as well as here, and also take a look at this site:

http://www.CPn Help.org/

For me CRABs were not an option because I had very aggressive progressive disease. The progression literally ground to a halt overnight.

Sarah
An Itinerary in Light and Shadow Completed Dr Charles Stratton / Dr David Wheldon abx regime for aggressive secondary progressive MS in June 2007, after four years. Still improving with no relapses since starting. Can't run but can paint all day.
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Postby viper498 » Wed Oct 12, 2005 10:58 am

Yeah but everything I have read points to the ABX not working as an anti-biotic in MS, but that there was another action taking place, a complimentary /anti-inflammatory action via the tetracycline. Why would paratek go to the expense of developing a drug without anitbiotic if it wouldn't help? Are they confused?

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Postby Anecdote » Wed Oct 12, 2005 12:36 pm

Hello Puff Adder(!),

The tetracyclines undoubtedly have some anti inflammatory effect, but in the trial finished last year at Vanderbilt University, the two antibiotics were chosen specifically because they had no anti-inflammatory qualities: rifampicin and azithromycin.

http://thisisms.com/modules.php?name=Forums&file=viewtopic&t=1406

and

http://thisisms.com/modules.php?name=Forums&file=viewtopic&t=1252&start=0

Paratek are not confused, just working along slightly different lines than Vanderbilt and my husband. Doxycycline and the rest wouldn't have changed the course of my disease to the extent it has if it was just due to anti-inflammatory qualities, because in SPMS inflammation is not supposed to play a very big part. Also I am now on intermittent therapy, with no return of symptoms in the two moth periods where I don't take any abx.

Have you not read either of the links I gave you in the previous post? :?

Sarah
An Itinerary in Light and Shadow Completed Dr Charles Stratton / Dr David Wheldon abx regime for aggressive secondary progressive MS in June 2007, after four years. Still improving with no relapses since starting. Can't run but can paint all day.
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