Bursting the elementary bodies

A forum for the discussion of antibiotics as a potential therapy for MS

Bursting the elementary bodies

Postby SarahLonglands » Fri Oct 14, 2005 4:33 am

David has done a lot of work to his web site, which is worth a look http://www.davidwheldon.co.uk/ms-treatment.html
This page is especially worth a look:

Easing mitochondrial stress in chronic Chlamydia pneumoniae infections: the use of dietary supplements

http://www.davidwheldon.co.uk/supplement_rationale.html

and especially this:

http://www.davidwheldon.co.uk/NAC.html

Bursting the elementary bodies


The protein coat which surrounds and protects the chlamydial elementary body relies on disulphide bonds within and between macromolecules to maintain its conformity. Reduction of these bonds disrupts the conformational integrity: such disruption would be expected to be irreversible. Penicillamine, and amoxycillin (whose major metabolite is penicillamine) have been demonstrated to inactivate EBs in vitro. [Chuck Stratton, personal communication.]

As the EB attaches to the host cell a number of different mechanisms seem able to allow entry. [Reynolds, D. J., and J. H. Pearce. Endocytic mechanisms utilized by chlamydiae and their influence on induction of productive infection. Infect. Immun. 1991; 59: 3033–3039.] Raulston and co-workers have shown that the disulphide bonds between the chlamydial surface proteins must be opened up just prior to or during attachment to the host cell. [Raulston JE et al., Surface accessibility of the 70-kilodalton Chlamydia trachomatis heat shock protein following reduction of outer membrane protein disulfide bonds. Infect Immun. 2002; 70(2): 535-43.] It is reasonable to think that, were the EB coat to be opened up before achieving attachment to a host cell, the unprotected EB would perish...........................................



Sarah
An Itinerary in Light and Shadow Completed Dr Charles Stratton / Dr David Wheldon abx regime for aggressive secondary progressive MS in June 2007, after four years. Still improving with no relapses since starting. Can't run but can paint all day.
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Postby yguner » Fri Oct 14, 2005 5:10 am

Thanks alot for this great info.
On CAP's protocol for Cpn in PPMS since June 2004 - Currently: Doxy 100mgx2/day - Roxy 150mgx2/day - Flagyl 500mgx3/day (Continuous protocol since sept.2006)
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