2 months of antibiotics

A forum for the discussion of antibiotics as a potential therapy for MS

2 months of antibiotics

Postby jaspreetdr » Thu May 05, 2011 8:04 am

Dear friends,
I had an attack of weakness in both legs with some bladder issues about three years ago. Diagnosed as transverse myelitis by a single lesion showing up in dorsal spine. Since then very slowly i have progressed downhill. Repeated mri show same lesion becoming long over 8 segments and with steroids shrinking back. However the weakness in legs kept increasing. Two months ago i started doxy+azi and pulse of metro. first cycle went uneventfully except for some burning sensation in feet. no herxreaction was noted. now doing my second pulse. do you think my absence of any reactions is bad sign. generally i feel increased energy but no improvement of gait as yet. Should i use some more antibiotics or wait
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Postby SarahLonglands » Fri May 06, 2011 8:32 am

Hello Jaspreet,

As you say on the LDN forum, you might well have PPMS, very treatable with antibiotics as is transverse myelitis. If you have only done one pulse of metronidazole, you might well not have had a reaction, but watch out for the next one. It might take you by surprise. My husband treated me and here is a link to a post he made on a different site just a few days ago about just what you are asking:

http://www.CPn Help.org/anyone_had_no_reaction_fl

"The ‘die-off’ reactions seem to depend on a number of factors.

Metronidazole’s active metabolites sever bacterial DNA at the AT bond. A critical number of these bonds have to be broken before bacteria die and release their endotoxinsi. In my case, the first pulse of metronidazole did nothing; the second pulse made the earth move.

The second consideration is the bacterial loadi. People with multisystem problems do seem likely to have a high bacterial load and often seem to have unpleasant ‘die-off’ reactions. Others may have a more restricted bacterial load and have very few reactions.

The third consideration is that of personal susceptibility to bacterial endotoxins; some individuals react much more strongly to neisserial endotoxins than others, and it would be reasonable to think that this variation would apply to chlamydial endotoxins as well. (Chlamydial endotoxins are very much weaker than neisserial and enterobacterial endotoxins.)

So - one might conclude by saying that if you experience ‘die-off’ reactions, that’s great; if you don’t, that’s even better."

The site might be quite useful for you to join: http://www.CPn Help.org/ It deals with many of the diseases caused by Cpn.

Incidentally, please click on the link and then make a note of the site's real address, because it gets changed here.......................Sarah
An Itinerary in Light and Shadow Completed Dr Charles Stratton / Dr David Wheldon abx regime for aggressive secondary progressive MS in June 2007, after four years. Still improving with no relapses since starting. Can't run but can paint all day.
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Postby jaspreetdr » Sun May 08, 2011 5:12 am

Dear Sarah,
Thanks for your knowledge. Another thing which comes to my mind is that during my first pulse of metro i noted increased burning sensation in my worse foot. This went away on finishing the pulse. And again similar sensation coming during my second pulse. I haven't noted this in many posts i have gone through. Has anybody else also experienced this?
Thanks again for the hope and encouragement i get on coming to this forum.
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Postby SarahLonglands » Sun May 08, 2011 6:51 am

Oh yes, increased burning which finishes after the pulse is certainly something that occurs and is nothing to worry about. I'm sure it has been mentioned somewhere: some people talk about every last little itch whereas others, like me, tend to just get on with things..................Sarah
An Itinerary in Light and Shadow Completed Dr Charles Stratton / Dr David Wheldon abx regime for aggressive secondary progressive MS in June 2007, after four years. Still improving with no relapses since starting. Can't run but can paint all day.
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Postby Looking88 » Tue May 10, 2011 12:12 pm

Could it be that somebody said some good news good about PPMS? Very treatable with antibiotics?

I am so used to PPMS being the condition that is not treatable (although some would say that Stem Cells can treat PPMS, so don't anybody give up hope).

Is there a breakdown of antibiotic effectiveness by type of MS?

Thanks,
Looking88
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Postby Abe » Thu May 12, 2011 3:44 am

Hi Looking88,

No there is no such research. I am as yet undiagnosed, though my symptoms indicate PPMS. I followed the Wheldon protocol for a little over a year to good effect. I'm convinced that CPn infection is one of the multifactorial causes and processes of MS. I am very glad that I undertook the treatment and thankful that information was shared here.

Kind wishes,

Abe
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