You and I are almost parallel on this. I am certain there are very few in the history of MS who have improved symptomatically enough to the level that Avonex no longer gives a weekly boost. I am PPMS and never improved. It has now been close to 5 weeks for me since I had a shot (Dec 8, 2005. I realized early in Nov. that I was not getting much from Avonex and having my liver functions always rising into a level of concern the day after my shot and going back to normal a day or so later even when I was on all 4 abx was another reason to give stopping it serious consideration. Dr. R, who gave me the shot, also expressed concern repeating over and over "Do you want your Avonex?" Every day that goes by makes me more certain that I have done the right thing. Unfortunately, those "experts" into whose hands we so gratefully handed our fate, don't know as much as we do about living with this. I, for one, am NOW, not in the past, better off without it. Best luck.
2010 5 years 4 months Now on Amoxicillin, Doxy, Rifampin, Azith, and caffeine in addition to flagyl. 90% normal good days-50% normal bad days. That is a good thing.