I read several posts here with regard to reactions to and side effects of abx. I think if someone is on the Vanderbilt or Wheldon protocol for a long time, the most important thing would be to gather info on handling the side effects of or reactions to the abx from those doctors ( Sriram, Stratton, Wheldon, etc.) who apply this treatment protocol.
As none of our doctors have experience with this protocol (they just do prescription as a favor), it would be really valuable to help their work. In general, doctors are used to giving drugs to a patient and if any side effects occur they stop and try a different drug if neccessary. Obviously, in this case no doctor knows what to do if such thing happens as they are not trained treating MS with abx. They do not know if they can stop one or more of the abx to see if they caused the problem or if they can try a new abx, take a pause, etc.
I would assume that those doctors at Vanderbilt must have encountered this problem. Unfortunately, when I tried to contact dr. Sriram he refused to give any advice. I understand that he can not recommend taking abx for MS, but I do not understand why he can not say anything about handling side effects of or reactions to abx in general. There are plenty of forums on the net where doctors answer questions without being held liable for any advice.
Just a few side effects the leaflet attached to the drugs indicate:
All medicines can have unwanted effects. Sometimes they are serious, most of the time
they are not. Do not be alarmed by this list of possible side effects. You may not
experience any of them.
Tell your doctor if you notice any of the following and they worry you:
• Oral thrush with a white, furry, sore tongue and mouth.
• Vaginal thrush with a sore and itchy vagina and/or discharge.
• Nausea, vomiting, stomach pain, diarrhoea, flatulence.
• Red and/or itchy skin.
• Headache, tiredness, dizziness, ringing in the ears.
• Loss of appetite.
• Altered taste.
These are the more common side effects of Roxithromycin-RL. Mostly, these are mild
If any of the following happen, stop taking Roxithromycin-RL and tell your doctor
immediately, or go to Accident and Emergency at your nearest hospital:
• Swelling of the face, lips, mouth or throat which may cause difficulty in swallowing
• Severe persistent diarrhoea.
• An allergic reaction, as itchy skin, rash, swelling, asthma.
These are very serious side effects. You may need urgent medical attention or
hospitalisation. All of these side effects are very rare.
Tell your doctor immediately if you notice any of the following, in particular if they
occur several weeks after you finished taking Roxithromycin-RL:
• Severe abdominal- or stomach cramps.
• Watery and severe diarrhoea, which may even be bloody.
• Fever, in combination with one or both of the above.
These may be rare but serious side effects of Roxithromycin-RL. You may suffer from a
serious condition affecting your bowel. You may need urgent medical attention. Do not
take any medicine for diarrhoea without first asking your doctor.
Other side effects not listed above may also occur in some people. Tell your doctor if you
notice any other effects
Possible side effects:
Like all medicines, Doxycycline capsules can cause side effects,
although not everybody gets them.
Stop taking the capsules immediately and seek urgent medical
• you notice that your skin is very sensitive to light (you may get
a skin rash, itching, redness or severe sunburn when out in
sunlight or after using a sun bed).
Contact your doctor at once if the following reactions happen:
• wheeziness, difficulty in breathing, fever, sudden swellings
of the face, lips, throat, tongue, hands or feet, fast heart rate,
low blood pressure, rash or itching (especially affecting the
whole body), pericarditis (inflammation of the membrane
surrounding the heart)
• swollen tongue, watery diarrhoea, fever and cramps
(pseudomembranous colitis), soreness and itching around the
back passage and/or genital areas, inflammation around the
vagina, or thrush of the vagina or mouth
• worsening of systemic lupus erythematosus (SLE).
Tell your doctor if you notice any of the following side effects or
notice any other effects not listed:
• Blood: altered numbers of certain types of blood cells, you may
notice that you bruise easily, have nose bleeds, or suffer from
infections and sore throats, porphyria (sensitivity of the skin to
sunlight, inflammation of nerves and stomach pains).
• Glands and hormones: discolouration of thyroid tissue (does
not affect thyroid function).
• Central nervous system: headache, increased pressure in the
skull (severe headaches, blurred and/or double vision, blind
spots), permanent loss of vision, bulging fontanelles (soft spot
on head) of infants.
• Ears: tinnitus (ringing or buzzing in the ears).
• Gastrointestinal tract: stomach pain, loss of appetite, feeling
or being sick, heartburn, diarrhoea, difficulty swallowing, sore
or painful tongue or mouth, inflammation and/or ulcers of the
gullet, discolouration or underdevelopment of teeth.
• Liver: changes in liver function tests, inflammation of the liver
(hepatitis), jaundice (yellowing of the skin or white of the eyes),
liver failure and inflammation of the pancreas (pancreatitis)
• Skin: severe skin reactions such as erythema multiforme
(circular, irregular red patches), Stevens-Johnson syndrome
(rash with flushing, fever, blisters or ulcers), toxic epidermal
necrolysis (reddening, peeling and swelling that resembles
• Muscles and bones: muscle or joint pain.
• Kidneys: an increase in urea in the blood.
If you notice any side effects, they get worse, or if you notice any
not listed, please tell your doctor or pharmacist.
Possible side effects:
Like all medicines Fasigyn may cause side effects, although not everybody gets them.
Tell your doctor immediately if you experience any of the following symptoms after taking this medicine.
Although they are very rare, the symptoms can be severe.
• Sudden wheeziness, difficulty in breathing, swelling of eyelids, face or lips or tongue, rash or itching (especially affecting the whole body).
The following side effects are rare with Fasigyn and you should contact your doctor as soon as possible if any of the following occurs:
• dizziness or vertigo
• numbness, tingling, pain or weakness in hands or feet
• clumsiness or unsteadiness
• fits or seizures
• fever or chills and painful ulcers in the mouth or bottom (rectum)
• sore or swollen mouth
• redness of the face or neck.
The most common side effects that occur in people taking Fasigyn are listed below. These may go away during treatment as your body adjusts to the medicine. Tell your doctor if any of these side effects continue to bother you.
• nausea (feeling sick) or vomiting, loss of appetite,
• diarrhoea, stomach pain or cramps
• headache or tiredness
• furry tongue or unpleasant metallic taste
• dark urine
Fasigyn can sometimes cause a temporary reduction in white blood cells which does not usually give you any symptoms.
If any of the side effects gets serious or you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.