Pubmed 11371760 wrote:
The tropism of C. pneumoniae to the neural tissue suggests it may play a role in diverse neurologic diseases, including Alzheimer's disease, multiple sclerosis and giant-cell arteritis.
That's only one of many citations, but, to a small extent, you are right: there are a vast number of people that are infected with C. pneumoniae
whom have not developed MS. They may develop altogether different kinds of diseases, either fulminant or forme fruste, including reactive arthritis, atherosclerosis and even asthma. That does not mean one can outright exclude C. pneumoniae's
involvement with multiple sclerosis.
The very nature of the bacterium, and the disease it is capable of producing, especially after prolonged chronic infection, is almost impossible to study according to Koch's postulates, the standard for associating pathogen with disease: 1. culturing the pathogen from diseased individuals [accomplished, Sriram et al. 1999.]; 2. infecting healthy organism with said cultured bacterium and observing subsequent disease state [not likely to happen with C. pneumoniae
, but Barry Marshall did it with H. pylori
and gastric ulcers, e.g., simply because of how quickly gastric ulcers develop]; 3. observing similarities between original culture and newly-infected culture [again, unlikely to happen in an experiment].
This is precisely why DW writes the following:
David Wheldon wrote:
An elucidation of the possible events which may happen in the course of persistent infective states with this organism will present one of the greatest challenges in medical microbiology in this century.http://www.davidwheldon.co.uk/peer-review.html