C. pneumoniae in post-mortem brain tissue, not in controls

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C. pneumoniae in post-mortem brain tissue, not in controls

Postby CuriousRobot » Fri Mar 22, 2013 5:09 pm

Could past Chlamydial vascular infection promote the dissemination of Chlamydia pneumoniae to the brain?
Chlamydia pneumoniae, a pathogen responsible for respiratory tract infections, has been associated with atherosclerosis which, along with hypertension, hyperlipidemia, cardiovascular and/or cerebrovascular ischemia and stroke, is a risk factor for chronic neurological disorders. Several studies have demonstrated the ability of C. pneumoniae to disseminate from lungs to arteries through peripheral blood mononuclear cells. Once inside the vascular tissue, C. pneumoniae infection may disseminate via peripheral monocytes to the brain over the intact blood-brain barrier, and contribute to the development of chronic neurological disorders. The aim of our study was to evaluate whether past C. pneumoniae vascular infection may promote the dissemination of this microorganism to the brain, therefore we investigated the presence of C. pneumoniae in post-mortem brain tissue specimens of patients with past chlamydial vascular infection. Seventy six post-mortem brain tissue specimens from 19 patients with past chlamydial vascular infection were investigated for the presence of C. pneumoniae by immunohistochemistry, polymerase chain reaction, in situ polymerase chain reaction and in situ reverse transcription polymerase chain reaction. As control, 28 brain tissue specimens were taken from 7 age and sex matched subjects without chlamydial infection. C. pneumoniae was detected in 16 (84.2%) out of 19 patients with chlamydial vascular infection whereas it was not detected in control subjects (p= 0.0002). In conclusion, the main result of our study is the evidence that a chlamydial vascular infection can disseminate to the brain. It will be important for current and future researches to perform large-scale prospective studies on cardiovascular patients with chlamydial vascular infection in order to evaluate the long-term pathological alterations of the brain.
http://www.ncbi.nlm.nih.gov/pubmed/23489695

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Re: C. pneumoniae in post-mortem brain tissue, not in contro

Postby SarahLonglands » Sat Mar 23, 2013 8:29 am

Interesting: I have forwarded this to David.......................Sarah
An Itinerary in Light and Shadow Completed Dr Charles Stratton / Dr David Wheldon abx regime for aggressive secondary progressive MS in June 2007, after four years. Still improving with no relapses since starting. Can't run but can paint all day.
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Re: C. pneumoniae in post-mortem brain tissue, not in contro

Postby CuriousRobot » Sat Mar 23, 2013 9:55 am

Thanks Sarah! I was thinking of doing the same...
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Re: C. pneumoniae in post-mortem brain tissue, not in contro

Postby SarahLonglands » Sat Mar 23, 2013 11:16 am

Do so: he would like to hear from you!
An Itinerary in Light and Shadow Completed Dr Charles Stratton / Dr David Wheldon abx regime for aggressive secondary progressive MS in June 2007, after four years. Still improving with no relapses since starting. Can't run but can paint all day.
SarahLonglands
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Posts: 2109
Joined: Thu Jun 17, 2004 3:00 pm
Location: Bedfordshire UK


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