Can you provide specific details regarding your symptoms?
1. Is it tightness or soreness?
2. Is there a considerable loss in range-of-motion, or you feel somewhat weaker?
3. Have you done any activity out of the ordinary in the past days or so (even something like walking an unused-to distance)?
4. Any specific anatomy affected, be it calves, hamstrings, glutes, adductors, hip girdle, flexors, etc.?
According to the premise, C. pneumoniae
will inhabit numerous locations in the body, including synovial membranes which are situated near large, anatomical joints. Upon administration of metronidazole, the bacterium is "littering the tissues with bacterial corpses, proteins, lipopolysaccharides and nucleic acids," essentially promoting local inflammation at the site of destruction [link
]. Might minocycline have a similar effect not on C. pneumoniae
, per se (obviously not), but on other bacterium that are latent in the synovium? I can't see why it is not possible.
There can be another explanation for this effect you are experiencing. I am not a physician.