Fantastic information. It would be wonderful for David Wheldon, Anecdote's husband, to take a good look at this article and see how it fits in with his research.
Arron, he might well when he has the time, but I thought I would just butt in here and probably in the process say just what he would think:
If minocycline or doxycycline are only useful for their neuroprotective qualities, then how is it that after six months of doxycycline I was switched, at Charles Stratton's recommendation to rifampicin, which is not neuroprotective at all and the improvements carried on. Now I have gone for two months without taking any antibiotics at all and the improvements are still slowly, bit by bit, carrying on. Basically, I have had no adverse event for 16 months now. Surely if the tetracyclines were only useful in MS for their neuroprotective qualities, after eight months without neuroprotection I would be feeling somewhat the worse for wear?
If you are taking any other drug, say betaferon or whatever, if you stop it any benefits you might have gained are lost, so I imagine it is the same for a tetracycline unless it is taken as an antibiotic to get rid of an infection.
The most promising news I have seen regarding Minocycline is Serono's statement that they are developing a non-antibiotic isomer. Hopefully, as an isomer of an already approved drug it will not have to go through the full FDA approval procedure and will become available much sooner because of this.
Surely this will mean that anyone taking one of the new non-antibiotic tetracyclines will have to take it continuously for full effect, not just be able to stop it, with the occassional booster dose for a couple of weeks every two or three months for a year or so?