Aubagio MS drug by Sanofi

Aubagio is an oral treatment approved for MS.

Aubagio MS drug by Sanofi

Postby lyndacarol » Wed Jun 06, 2012 5:54 pm

Aubagio, MS drug by Sanofi, is new to me:

http://www.reuters.com/article/2012/06/ ... 8820120601

Positive test boosts Sanofi MS drug hopes
Fri, Jun 1 2012
By Christian Plumb and Elena Berton

PARIS (Reuters) - Sanofi reported positive results from a late-stage trial of its Aubagio multiple sclerosis drug, bolstering its chances of approval by regulators as it seeks to catch up with a fast-selling oral treatment from rival Novartis.

Sanofi said it found that a daily dose of the treatment, one of two multiple sclerosis drugs it has in late-stage development, reduced the rate of relapse by 36 percent compared with a placebo.

The study assessed the efficiency and safety of Aubagio in 1,169 patients with relapsing forms of multiple sclerosis.

The full data from the study will be presented at an upcoming scientific meeting, Sanofi said.

Cheuvreux analyst Marcel Brand, who has an "outperform" recommendation on Sanofi stock, said the results were positive and consistent with earlier data, "which is reassuring".

Brand expects Aubagio to generate peak sales of $1.8 billion in 2018, taking around 11 percent of volume market share.

The U.S. Food and Drug Administration (FDA) and European Medicines Agency (EMA) are both reviewing marketing applications for Aubagio as a treatment for relapsing forms of MS.

The FDA's response is due by July 2012, while EMA is expected to give its feedback in the first quarter of 2013.

Compared with older therapies, Aubagio has the advantage of being an oral drug.

But it has produced less impressive results in clinical tests than other oral MS treatments and has failed to show it was better than a commonly used injectable drug for MS, although it did have milder side effects.

Analysts expect the drug could find a niche among newly diagnosed patients, since around 35 to 40 percent of MS patients prefer to take no medication rather than face unwanted side effects.

MS pills Gilenya by Novartis and Biogen Idec Inc's BG-12 are seen dominating a market that JPMorgan analysts predict growing to $14 billion in 2015 from $9.6 billion last year.

MS, which has no cure, affects 2.5 million people worldwide. It is a chronic, often disabling disease that attacks the central nervous system and can lead to numbness, paralysis and loss of vision.

Sanofi shares, which have declined around 3.5 percent since the start of the year, were trading 1.2 percent lower at 54.34 euros at 0935 GMT, matching a fall in the CAC 40 index.

(Reporting by Christian Plumb and Elena Berton; Editing by Mike Nesbit and Jon Loades-Carter)

© Thomson Reuters 2011. All rights reserved
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Re: Aubagio MS drug by Sanofi

Postby dignan » Thu Jun 07, 2012 7:59 am

Until recently, it was called teriflunomide. I guess as it got close to approval, the marketing folks got their hooks into it and came up with Aubagio.
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Re: Aubagio MS drug by Sanofi

Postby CureOrBust » Thu Jun 07, 2012 5:20 pm

OR the marketers did not wish to go to market with poor results attached to the label "Teriflunomide" as compared to the hype and mystique that could be generated about a "NEW" drug.

PS: its good to hear from you dignan, you have been missed by some of us.
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Re: Aubagio MS drug by Sanofi

Postby gibbledygook » Sat Jun 09, 2012 11:51 am

I guess it's just the same as Leriflunomide for RA. I mean it's pretty lame (ho ho) just to change one letter...
3 years antibiotics, 06/09 bilateral jug stents at C1, 05/11 ballooning of both jug valves, 07/12 stenting of renal vein, azygos & jug valve ballooning,
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