I have been taking this drug since 2007. I was in Phase III and have been extended multiple times. I am still on the drug provided by the MS clininc until October 2014. I am not sure what dose I was on for the first 2 years, or maybe the placebo, but after the 2 years were up, I am on the real thing. Now we are 5.5 years popping these pills once daily, and in the last 2 years, I found that my hair at the top of my head, closer to the front, has definitely thinned. I am now 57 so thinning and hair loss is a possibility, but compared to 2 years ago, there is definitely a noticeable difference. Most people cannot tell as I still have hair, but I know, as does my wife and barber. I lay in bed reading my smartphone in the dark and all I see are hairs falling out of my head onto the lit screen. I am not impressed. I am sad. My mop of hair, especially for a 57 year old is slowly thinning and balding. Then I have to ask myself whether vanity or the hardships of MS, which is the better choice. I had one minor episode at 52 for 3 weeks, and none since. Do I take my chances or stay on the drug til the end of the trial, altho not really a trial anymore, just waiting to be legalized in Canada or not. So I fret everytime I take the pill. I watch my hair continue to thin in the front altho wife says much thicker in the back now, pray I still have lots of hair by Oct 2014, and decide what I will do then.