Teriflunomide

Aubagio is an oral treatment approved for MS.

Postby tobi » Sat Dec 12, 2009 9:14 am

here you can look for the different teriflunomide trials:

http://clinicaltrials.gov/ct2/results?term=teriflunomide[/url]
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New to the Site- Thinking of Teriflunomide Clinical Study

Postby domheldercamara » Fri Dec 18, 2009 6:05 pm

My MD asked me if I was interested in participating in the phase III study as I am pretty well petrified of needles...
I am reading the consent form and it says something to the effect that the drug has shown (in test tube studies) alterations to DNA- and can potentially cause cancer..but there is no proof yet in humans.
:roll:
It makes me equally nervous.
Can anyone speak to the effects the drug has had on them. I understand that hair loss is one of them- its the cancer that really scares me, any words of advice?

Thanks :)
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Postby DM » Fri Dec 18, 2009 6:14 pm

Dom,

I'm in Ottawa as well. Just finished up the 2 year trial. Now I am on the expanded trial. Except for some thinning of the hair, no sidefx whatsoever.

Don't worry about it. They'll look after you well with frequent visits, ultrasounds, and MRIs.

Guess you are at the General?
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Teriflunomide

Postby domheldercamara » Sun Dec 20, 2009 9:15 pm

Hey DM,

Thanks for making me less nervous about teriflunomide. I will be at the General with Dr. Christie for the trials.

I am glad to know that there is someone on the forum not only in proximity, but on the same trial.

Thanks again, I think now I will have less trepidation to try this drug out.
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Postby DM » Fri Jan 01, 2010 4:07 pm

It may be the same drug but a different trial. As far as I know, I was the last at the clinic to be in the particular study.
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Postby Jaguar » Wed Jan 06, 2010 11:55 am

I have been in trials for I think it is now 8 years. Definite hair thinning - happened right at the beginning, then stopped.

But hey, I'm a guy, what can I really expect?
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Postby DM » Wed Jan 06, 2010 12:52 pm

Did it just stop, or start to grow back a bit once the body adjusted to the drug?
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Postby Jaguar » Wed Jan 06, 2010 1:15 pm

No growing back

just thinner and thinner over 4 years or so
now stable
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Postby DM » Thu Jan 07, 2010 8:34 pm

At the rate its going lately, I won't have any left in 2 years, and I did have a lot of hair on my head. I am not happy!
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Bad news

Postby MartynW » Fri Jan 22, 2010 8:48 am

So, it seems I have 3 new lesions, so am washing out of the drug next week. Oh well, was worth a try. 9 months, no symptoms, perhaps the Placebo, will never know.

Looking into Avonex now.

tbh, its good timing, i was about to go travelling for a year, and the drug company was insist that i travel back to London every 6 weeks for blood tests, which would have been expensive.

Still don't have MS by definition, but as the Doctor says "the ongoing activity is highly suggestive".

Good news in the paper yesterday

Hope for MS pill after cladribine and fingolimod trials
http://news.bbc.co.uk/1/hi/health/8470138.stm
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Postby sneakypuss_01 » Mon Apr 19, 2010 4:56 am

Hi All

Just wanted to let you know that I am participating in the phase III trial here in Australia.

I get put into 'randomization' ion May 4th. So far, I am only the second person at my MS Clinic to go into the trial.

Hope everyone is well.
Sneaky P
There's not brain lesions...their bright ideas.
DX July 1st 2009 RRMS
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Postby sneakypuss_01 » Tue Apr 20, 2010 11:19 pm

For those interested in the trial, here's the offical website:

http://tower3.msstudies.com/index.php
There's not brain lesions...their bright ideas.
DX July 1st 2009 RRMS
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Postby DM » Wed Apr 21, 2010 2:34 pm

I completed the Phase 3 trial this past November. Haven't found out yet what I was taking. On the extended study now, and on the real thing, 7 or 14mg. No noticeable differences except my hair has thinned. No sfx whatsoever. Good luck and let us know how you progress!
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Postby sneakypuss_01 » Tue May 04, 2010 3:51 am

Hey DM

Well, I got given something today...frustrating that we can't know what it is, but I do understand why.

Will definitely keep you posted on my progress.
There's not brain lesions...their bright ideas.
DX July 1st 2009 RRMS
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Re: Teriflunomide

Postby DM » Tue Jun 26, 2012 1:00 pm

It has been a while since my last post. I am still on the extended study, still not knowing what I was taking during the trial, several years ago. As of now, I am scheduled to be off the drug in June 2013, unless it gets extended once again. My ultrasounds have stopped although the MRIs continue.

I have had no side FX whatsoever, and the toughest thing is remembering to take the pills. I must have downed hundreds of these lil guys already, and I feel no different. Maybe that a good thing since I have no ill FX from the MS whatsoever.

My hair is still thinning and at this rate, I will be bald in 3 years. Still have a chunk of good hair as long as I dont comb it but when it is wet, like out of the shower, my scalp is visible. Wait til it dries and no one knows the difference.

My nurse says that they are having good success with this drug, maybe they are, I do not know, but it has not bothered me whatsoever. Doubt it the cure but maybe in keeps the MS in check. 7mg or 14, couldn't tell you. Not til they open the books when everything is said and done. Sure happy I am not injecting myself.

So, another year and I guess that is it. After that, not sure.

Anyhow, just thought I would chime in after not being here for so long
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