Teriflunomide

Aubagio is an oral treatment approved for MS.

teriflunomide

Postby cfwin » Mon Oct 17, 2005 10:13 pm

Let me know how it goes for you. I have had a very good experience on this drug! Where are you located? I am in Southern Ontario, and visit the MS clinic at the LHSC.
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Postby dpdsc » Tue Oct 18, 2005 4:39 am

I think I might be on the placebo because since I've been on it my flareups have been worse, but I will let you know. Did you hear that they have found problems with the drug in animals (pancreas and liver)? I had to go for an ultrasound two weeks ago to make sure everything was okay. I'm from Montreal, I go the MS Clinic on the south shore.
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Postby Melody » Tue Oct 18, 2005 9:13 am

I have a friend on it at St. Mikes this is what happened last time back in September.

Hi Melody;
I forgot to tell you.
Trip to St. Mikes O.K. I guess.There wasn't an MRI so I was back by mid afternoon.. They say I have been doing O.K.. There was one surprise.They want me back very soon for a bowel or stomach catscan becasue the drug has caused pancreas problems with dogs but he says don't worry there have been no problems with humans. Shees ! I don't know what to do about that.
Gotta run. Talk to you later this afternoon.
Cal



Now since then he has been checked and all was fine for him
John was diagnosed Jan 2005. On lipitor 20mg .On Copaxone since July 4,2005. Vitamin D3 2000iu-4000iu (depending on sunshine months)June 10 2005(RX::Dr. O'Connor) Omega 3 as well Turmeric since April 2005. Q10 60mg. 1500mg liquid Glucosamine Nov 2005.
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Postby gottens » Mon Jan 23, 2006 6:39 am

I have been on Teriflunomide since May 2005 and so far everything seems to be fine. I have had no more attacks, but I was only diagnosed just over a year ago and am not sure what to expect anyways. This drug sounds hopeful. I would like to hear from more people that were on the first trial.
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Postby dignan » Mon Jan 23, 2006 10:11 am

Gottens,
So you must have been in a Phase II trial of teriflunomide then? Did you find out after the fact that you were in the placebo group? Curious to hear about your experiences...
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Postby gottens » Sat Jan 28, 2006 8:58 am

I just started the trial last year. I thought it was phase II but I guess it is phase III. However, I don't know whether I am on the real thing or just the placebo. Only time will tell I guess. But so far, so good!
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Postby hazel » Thu May 25, 2006 12:41 pm

I've been asked to participate in Phase III of the study. I was a little reluctant when I read the consent form, but after reading all the postings from those on Phase II, I've decided to say yes. I'm being tested next week to ensure I am a good candidate.

I'll keep you posted.
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Postby Arron » Thu May 25, 2006 2:03 pm

Welcome to the site, Hazel. Thanks for keeping us informed-- there are many that will be anxiously watching your results.
Disclaimer: Any information you find on this site should not be considered medical advice. All decisions should be made with the consent of your doctor, otherwise you are at your own risk.
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teriflunomide

Postby cfwin » Thu May 25, 2006 4:57 pm

Hi Hazel:

Is it a blind study...or do you know if you will be on the drug? I have been on teriflunomide for quite a few years now...currently in the continuation of the phase II trial.

All the best!
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teriflunomide

Postby hazel » Fri May 26, 2006 12:18 pm

It's a blind study. I won't know whether I am on the drug or on a placebo.

I will keep everyone posted.
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Postby DM » Fri Sep 07, 2007 8:57 am

No news sine May 2006?

Hi. I'm new to this site. I guess I have been diagnosed with MS this past July. I only had one event, back in Nov/Dec 2006, that lasted for approx. 3 weeks. Nothing serious at all. A slight nusance at best. Just some minor numbness at my fingertips on my left hand, and around the corner of my mouth, also on the left side. I went to the hospital approx 5 days later only to be diagnosed with a stroke. Anyhow, after the 2 MRIs several weeks later, the stroke was out and MS was in.

Currently, I have no symptoms whatsoever. I am fine! The doctors and nurses here in Ottawa have asked me to volunteer for this drug, or placebo, on a trial basis. I just received the documents (consent forms) and I am trying to determine if this is for me. I am 51 yrs old, and have never been on any medication in my life. I feel great, with nothing related to MS affecting me. It appears that there is a chance of several side affects, of which none interest me to get.

Can anyone shed some light as to the side affects and general overall feeling?

Thanks
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Teriflunomide Reduces Active Lesions in MS Patients

Postby lbfightsms » Wed Sep 26, 2007 7:59 pm

Teriflunomide Reduces Active Lesions in MS Patients

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NEW YORK (Reuters Health) Apr 21 - Treatment with teriflunomide, an oral dihydro-orotate dehydrogenase inhibitor, reduces disease activity with a trend towards fewer relapses in patients with multiple sclerosis (MS), according to the results of a phase II trial conducted by North American and European investigators.

Lead researcher Dr. Paul W. O'Connor told Reuters Health: "These findings are exciting in that they move us one step further to developing something that all MS patients on therapy want: an effective oral treatment."

All current MS drugs require administration by injection. However, teriflunomide, which can be given orally, has shown promise in animal models of autoimmune disease, Dr. O'Connor of St. Michael's Hospital, Toronto and colleagues note in the March 28th issue of Neurology.

To investigate further, the researchers studied 157 patients with relapsing-remitting MS and 22 with secondary progressive MS with relapses. The patients were randomized to 36 weeks of teriflunomide 7mg/day, 14 mg/day or placebo. MRI scans were conducted every 6 weeks.

MRI showed that the median number of combined unique active lesions per scan was 0.5 in the placebo group, 0.2 in the 7-mg group and 0.3 in the 14-mg group.

Patients in both teriflunomide groups had significantly fewer T1 enhancing lesions per scan, new or enlarging T2 lesions per scan and new T2 lesions. Patients in the higher-dose group also had a significantly reduced T2 disease burden.

Compared with placebo, significantly fewer patients in the higher-dose group showed a disability increase. These patients also showed a trend towards a lower annualized relapse rate and there were fewer relapsing patients. The treatment was well tolerated and the frequency of adverse events was similar across groups.

"A full phase III trial of this therapy will be necessary to establish a clinical benefit, and this is in progress at present in Canada, Europe, Australia and South Africa," Dr. O'Connor said.

Neurology 2006;66:894-900.
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Postby DM » Thu Sep 27, 2007 5:37 am

I am off to the hospital this morning (09/27/07) to get the final low down, and probably sign the consent forms. My health is still fine, and have no relapses whatsoever. I am not sure when I start this medication, but I shall keep you informed as to what effects I have, or don't.
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Postby gkalman » Tue Oct 09, 2007 3:17 pm

DM, nobody can tell you to do this or not to do it.

However, (1) you'll get someone to monitor your disease (being a post middle age at diagnosis makes you a high risk for very fast disease progression. It is especially true if you are a male.), (2) you'll have a good chance of receiving an oral drug that more likely than not would be better than twice as effective against the disease than a drug that is approved and you'll have to inject into yourself, (3) you'll be helping others (perhaps your own progeny).

The only things I would watch out for, is the attitude of the doctor. I.e., is the doctor more interested in your well being or the study? You definitely wish to be in the first category.
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Postby DM » Tue Oct 09, 2007 4:46 pm

Well, I signed off the consent forms. Did the blood and urine tests. Looked at by the chief MS doctor, as well as another Dr. Did some timed walking around the ward, placed pegs in the holes and removed them (timed), and did a math quiz. Everything went fine as far as I am concerned.

Now for the stomach/pancreas ultrasound on the 12th Oct., then back to the MS clinic on the 18th for blood tests, and whatever else. I think I start the drugs early November, for 2-2.5 years.

I feel I am a well qualified candidtae as I will provide an objective view as to what I am feeling. I am not in the position of hoping, and thriving for a cure. Actually, as I told the nurse, give me the pills. I don't give a damn. Why, you may ask? Because I have 0 symptoms. I am not seeking the miracle cure, but if the drug can potentially help others who are experiencing a progressed state of MS, I have done my bit for society.

What will be will be. If this is what life doles out, I have no choice. So far, I am extremely fortunate. The Drs. and nurses consider me extremely fortunate, along with the fact that my history is excellent. Although the lesions are not recent, to have held off for such a long time, who could have asked for more.

So, stay tuned, and I'll let everyone know what is going on. I may very well get the placebo, who knows. I shall let you know all that is going on with me. This is apparently the last phase of testing. After this phase, 2 years to sell it to the feds, and then intom production, I believe.

Will get back on October 18th.
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