Positive data from Avonex dose titration study reported

A board to discuss the Multiple Sclerosis modifying drug Avonex

Positive data from Avonex dose titration study reported

Postby MSUK » Mon Jun 06, 2011 8:36 am

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Biogen Idec has announced the findings from a randomized, multicenter, dose-blinded clinical trial that evaluated the effect of Avonex®(interferon beta-1a) dose titration, or gradual dose escalation, on flu-like symptoms associated with the therapy.

The data demonstrated that dose titration with Avonex over three weeks at the initiation of treatment resulted in a 76 percent reduction in flu-like symptom severity between pre-injection and the four-six-hour post-injection time point versus no titration (p<0.001).... Read More - http://www.msrc.co.uk/index.cfm/fuseact ... ageid/1765
MS-UK - http://www.ms-uk.org/
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Postby shaight » Mon Jun 06, 2011 1:52 pm

interesting. i'm reading this to say that the 3 week build-up was more beneficial than the 6 week? i am on the 6-7 week plan, meaning full shot at the 7th week.

Results showed that over the treatment period, change in flu-like symptom severity between pre-injection and the four-six-hour post-injection time point was reduced by 76 percent with Avonex titration over three weeks versus no titration, and by 50 percent with Avonex titration over six weeks versus no titration. Over the same treatment period, change in flu-like symptom severity between pre-injection and the 12-15-hour post-injection time point was reduced by 37 percent with Avonex titration over three weeks versus no titration and by 32 percent with Avonex titration over six weeks versus no titration.
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Postby shaight » Mon Jun 27, 2011 8:54 am

well, after reading this report i switched to the 3 week plan. i took my first full shot on saturday night. i had absolutely no side effects whatsoever. obviously, i'm not sure if i would have had any otherwise, but i am sold on the 3 week titration plan.
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