I usually inject between 8 and 10 pm (on Sunday nights). The vomiting seems to start happening to me about 3 to 7 am, so just a few hours after the injection. Also I usually am throwing-up Bile not food or it's mixed with food. (I had my gallbladder removed years ago.) I'm not sure if the bile part is relative or not.
I know that this may seem counterintuitive, but I found that injecting mid day around noon to be much better than injecting in the evening. I never was able to "sleep through the side effects." It seemed that my body would not thermoregulate well while sleeping on Avonex. I would get fevers and chills. One time I had the shakes so bad I could barely walk to the bathroom. Another time when I had the chills, I plugged in a small portable heater with an extension cord only to wake up in the morning and find the cord's receptacle partially melted. Anyways, by injecting during the day, I was better able to manage the side effects with ibuprofen and usually slept better. In addition, the side effects seemed less severe injecting earlier in the day.
For the side effect: My Neuro has me on Hydrocodone (that I only take when the pain gets unbearable). He's prescribed Tramadol for me to take as need (the medication I try to use instead of the Hydrocodone but never seems to work for me) I'm always in major pain after the injection when I take the Tramadol it doesn't help me. The Hydrocodone does work but I don't wanna take it often nor do I wanna become addicted to it. I will sometimes vomit off and on all day that day but other times it maybe on for a couple of hours.
I do take over the counter meds to help when I run out of my prescription(s). I have combined over the counter with Tramadol to see if it helps and it does a little bit. What I take is either Ibuprofen or Tylenol.
I had the worst fever I've ever had after taking my first injection. I took Tylenol and it seemed to do nothing for me. I was essentially incapacitated for ~ 12 hours and spent quite a bit of time laying on my bed with an ice pack on my forehead watching the color blobs on my ceiling. Afterwards, I called my doctor's nurse and told her that I didn't think I could continue with Avonex if it was going to be like that every time. She then suggested that I try ibuprofen and that it worked better for some people. Gee, I wish they had told me that in the beginning! Anyways, after a couple of years, I would feel the side effects start to kick in about an hour or so after my shot (my muscles would start to spasm and I would get these abdominal spasms where my upper body would just suddenly bend forward if I was sitting) and I would take 400 mg of ibuprofen and about 20 minutes later everything was much more manageable. It never ceased to amaze me every time.
Now your vomiting reaction sounds more severe. The reason that I suggested that you might have neutralizing antibodies is that there were a couple of recent posts from people on Tysabri that had similar problems and were diagnosed with neutralizing antibodies if I remember correctly. You might want to consider giving the Avonex a break until you can figure out this problem with your neurologist. There might be a better medication for you.
Thank you again NHE
Sure, no problem. I hope that you can get something figured out so you don't have to go through so much after every shot.