Transient episodes of hypotonia and/or severe muscle weakness that prevent voluntary movements may occur at any time during treatment. Thes episodes are of limited duration, temporarily related to the injections and may recur after subsequent injections
lyndacarol wrote:I am especially interested in AllyB's information from the Avonex package insert:Transient episodes of hypotonia and/or severe muscle weakness that prevent voluntary movements may occur at any time during treatment. Thes episodes are of limited duration, temporarily related to the injections and may recur after subsequent injections
I seem to recall that Avonex contains glucose – now I wonder if it can trigger excess insulin secretion, which migrates to the muscles (causing hypotonia). I know that insulin can permeate the blood brain barrier (can damage the blood vessels, ferries glucose to the muscles – excess insulin is known to stiffen and thicken the smooth muscles).
30 mcg Lyophilized Powder Vial A vial of AVONEX ® is formulated as a sterile, white to off-white lyophilized powder for intramuscular injection after reconstitution with supplied diluent (Sterile Water for Injection, USP). Each vial of reconstituted AVONEX ® contains 30 mcg of Interferon beta-1a; 15 mg Albumin (Human), USP; 5.8 mg Sodium Chloride, USP; 5.7 mg Dibasic Sodium Phosphate, USP; and 1.2 mg Monobasic Sodium Phosphate, USP, in 1.0 mL at a pH of approximately 7.3.
Longing4Cheese wrote:Too bad I have to wake up in the middle of the night to take more ibuprofen...sleep disruption is a drag, but, then, so are flu-like symptoms, which I avoid almost completely if I stay up on my ibuprofen (every ~4.5 hours I take 600mg).
lyndacarol wrote:Thanks, NHE, for correcting my memory about the ingredients in Avonex. If not Avonex, doesn't one of the CRAB drugs contain a sugar? Or has my memory gotten so bad?
30 mcg Prefilled Syringe:
A prefilled syringe of AVONEX ® is formulated as a sterile liquid for intramuscular injection. Each 0.5 mL (30 mcg dose) of AVONEX ® in a prefilled glass syringe contains 30 mcg of Interferon beta-1a, 0.79 mg Sodium Acetate Trihydrate, USP; 0.25 mg Glacial Acetic Acid,ഊUSP; 15.8 mg Arginine Hydrochloride, USP; and 0.025 mg Polysorbate 20 in Water for Injection, USP at a pH of approximately 4.8.
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