Thanks, NHE, for correcting my memory about the ingredients in Avonex. If not Avonex, doesn't one of the CRAB drugs contain a sugar? Or has my memory gotten so bad?
To be fair, I should have also included the ingredients for the prefilled syringes since many people now use those.
30 mcg Prefilled Syringe:
A prefilled syringe of AVONEX ® is formulated as a sterile liquid for intramuscular injection. Each 0.5 mL (30 mcg dose) of AVONEX ® in a prefilled glass syringe contains 30 mcg of Interferon beta-1a, 0.79 mg Sodium Acetate Trihydrate, USP; 0.25 mg Glacial Acetic Acid,ഊUSP; 15.8 mg Arginine Hydrochloride, USP; and 0.025 mg Polysorbate 20 in Water for Injection, USP at a pH of approximately 4.8.
It does contain 25 micrograms of Polysorbate 20
. But the structure of this molecule doesn't even look close to any sugar or starch. Even if it was metabolized to the 5 member ring which sort of resembles a sugar, the low levels at 25 micrograms would not likely be significant.* It's presence is likely just to stabilize the Inf-B in solution.
* If we make an assumption about how a polysorbate 20 molecule might be metabolized such that the ether bonds surrounding the 5 member ring are hydrolized to hydroxyl groups, then the amount of "sugar-like" molecule would be reduced to 3.34 micrograms since the resultant molecular weight (164.18 g/mol) would be just 13.37% of the parent molecule's molecular weight (1227.54 g/mol).