Yes, it's pretty normal to feel like you've just been run over after taking Avonex especially after the first shot. Did you take anything to counter the side effects? I know that Biogen recommends taking some Tylenol but many people have found that ibuprofen actually works better. I would try a 400 mg dose of ibuprofen at the time of your shot and then about 2 more doses spaced every 4 hours afterwards. Hopefully, that will work better for you. For most people, the side effects tend to diminish in severity after the first few months but for others (as with myself) they can last longer.