Biotin "significantly improves" progressive MS-new study

Biotin is an emerging therapy for the treatment of secondary progressive MS.

Biotin "significantly improves" progressive MS-new study

Postby cheerleader » Fri Apr 03, 2015 8:41 am

http://www.ncbi.nlm.nih.gov/pubmed/25787192

In four patients with prominent visual impairment related to optic nerve injury, visual acuity improved significantly. Visual evoked potentials in two patients exhibited progressive reappearance of P100 waves, with normalization of latencies in one case. Proton magnetic resonance spectroscopy (H-MRS) in one case showed a progressive normalization of the Choline/Creatine ratio. One patient with left homonymous hemianopia kept on improving from 2 to 16 months following treatment׳s onset. Sixteen patients out of 18 (89%) with prominent spinal cord involvement were considered as improved as confirmed by blinded review of videotaped clinical examination in 9 cases. In all cases improvement was delayed from 2 to 8 months following treatment׳s onset.
CONCLUSIONS:
These preliminary data suggest that high doses of biotin might have an impact on disability and progression in progressive MS. Two double-blind placebo-controlled trials are on going.


Biotin is also known as vitamin B7. It is found in peanuts, leafy green veggies and egg yolks. It is naturally produced by healthy intestinal bacteria. Smoking and drinking can deplete it.
All of these ideas can be found in the Endothelial Health Program, which recommends probiotics, B vitamins, dietary increases in leafy veggies, and smoking cessation.
http://ccsvi.org/index.php/helping-myse ... ial-health

cheer
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dx dual jugular vein stenosis (CCSVI) 4/09
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Re: Biotin "significantly improves" progressive MS-new study

Postby PointsNorth » Fri Apr 03, 2015 9:19 pm

Thanks Cheer,

That's a high dose indeed. A compound pharmacy would be needed, maybe more.

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Re: Biotin "significantly improves" progressive MS-new study

Postby NHE » Fri Apr 03, 2015 10:40 pm

PointsNorth wrote:That's a high dose indeed. A compound pharmacy would be needed, maybe more.

See the other discussion in the Pipeline forum...
drug-pipeline-f13/topic25826.html#p231799
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Re: Biotin "significantly improves" progressive MS-new study

Postby cheerleader » Sat Apr 04, 2015 6:33 pm

NHE wrote:
PointsNorth wrote:That's a high dose indeed. A compound pharmacy would be needed, maybe more.

See the other discussion in the Pipeline forum...
drug-pipeline-f13/topic25826.html#p231799


thanks for the link, NHE---hadn't realized it was being patented as a pharmaceutical when I read the abstract.
Should have known better, right :?
Yeah, that's a re-e-a-lly high dosage. Take a lot of peanuts!

The animal model used were mice created w/severe biotin deficiency who developed demyelination, which was reversed after supplementation... but a deficiency is humans is rare. And it doesn't sound like MS. It shows up in the first few months of life.

Profound biotinidase deficiency, the more severe form of the condition, can cause seizures, weak muscle tone (hypotonia), breathing problems, hearing and vision loss, problems with movement and balance (ataxia), skin rashes, hair loss (alopecia), and a fungal infection called candidiasis. Affected children also have delayed development. Lifelong treatment can prevent these complications from occurring or improve them if they have already developed.
Partial biotinidase deficiency is a milder form of this condition. Without treatment, affected children may experience hypotonia, skin rashes, and hair loss, but these problems may appear only during illness, infection, or other times of stress.

http://ghr.nlm.nih.gov/condition/biotinidase-deficiency

Am I missing something here? NHE, you seem to understand the MOA on this, what is going on in humans w/MS?

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Re: Biotin "significantly improves" progressive MS-new study

Postby cheerleader » Sat Apr 04, 2015 7:20 pm

NHE--
Check this out. Found the patent application for this "drug"---
check out the section on ischemia and hypoperfusion.
The MOA is well-explained.
They are also patenting it for use after ischemic stroke.
http://www.google.com/patents/WO2014016003A1?cl=en

yeah, there's no vascular connection to MS...
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Re: Biotin "significantly improves" progressive MS-new study

Postby NHE » Sun Apr 05, 2015 12:43 am

cheerleader wrote:NHE--
Check this out. Found the patent application for this "drug"---
check out the section on ischemia and hypoperfusion.
The MOA is well-explained.
They are also patenting it for use after ischemic stroke.
http://www.google.com/patents/WO2014016003A1?cl=en

yeah, there's no vascular connection to MS...
cheer


Thanks for the link to the patent.

cheerleader wrote:Yeah, that's a re-e-a-lly high dosage


The highest dosage I've seen online as a supplement is 10 mg. I don't know what the potential toxicities are at 300 mg.
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Re: Biotin "significantly improves" progressive MS-new study

Postby Kronk » Sun Apr 05, 2015 10:13 am

I had taken Biotin in the past as I felt I may be taking to much malic acid, alpha lipoic acid and malic acid which deplete the body of it. I was taking the acids to support the KREBs cycle which is another topic… I didn’t notice anything while on it but i was taking only 5000mcg daily. This study had people taking a minimum of 100,000mcg daily. I did some reading on Biotin and there is a very interesting link to Glucose and Fatty acid metabolism.

Biotin intake has been associated with helping to fight and preventing diabetes, particularly type 2. Pairing biotin with chromium has been show to have an even greater effect. A study conducted at the Alpha Therapy Center in Corpus Christi, Texas found that, “a chromium picolinate/biotin combination…can improve glycaemic control in overweight to obese individuals with type 2 diabetes; especially those patients with poor glycaemic control on oral therapy.” A 2005 study found that, “Biotin deficiency has been linked to impaired glucose tolerance and decreased utilization of glucose.” Now I am not really in the CCVSI camp, but I do find it interesting that high Glucose affects the ability of endothelium muscles to relax.

More to my thinking biotin is also critical for fat metabolism in the body, which I strongly believe is impaired in MS. Multiple studies have shown fatty acids in the serum of MS patients are significantly skewed to Saturated fats with limited Unsaturated fats. The fatty acid profile makes us more susceptible to EBV replication and makes our cell walls to thick so their receptors are not accessible. I really hope more research comes out of this study. There has never been a report of Biotin toxicity, I have heard of side effects such as acne.

Study on Glycaemic control of biotin
http://www.ncbi.nlm.nih.gov/pubmed/17506119

Biotin deficiency and glucose tolerance
http://www.ncbi.nlm.nih.gov/pubmed/15992683

Elevated Glucose Impairs Endothelium-dependent Relaxation by Activating Protein Kinase C
http://www.ncbi.nlm.nih.gov/pmc/article ... 9-0167.pdf

THE EFFECTS OF BIOTIN UPON FAT SYNTHESIS AND METABOLISM
http://www.jbc.org/content/141/2/619.full.pdf

How Biotin Works
http://health.howstuffworks.com/wellnes ... biotin.htm

Serum Fatty Acids in MS
http://www.ncbi.nlm.nih.gov/pmc/article ... 69/?page=2
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