VITAMIN B7 FOR PMS

Biotin is an emerging therapy for the treatment of secondary progressive MS.

VITAMIN B7 FOR PMS

Postby seeva » Tue Jul 14, 2015 2:44 am

HI Friends last monad I met my nuro. he recommended me to take maximum. dose of BIOTIN which is vitamine B7.I ply found 3.00mg is the max
please readhttp://www.mstranslate.com.au/vitam ... essive-ms/
my nero. says news about tis will be soon
regards
seeva
User avatar
seeva
Family Elder
 
Posts: 453
Joined: Sun Jan 20, 2008 3:00 pm
Location: SYDNEY

Advertisement

Re: VITAMIN B7 FOR PMS

Postby nellie » Tue Jul 14, 2015 5:54 am

Hi Seeva. I can't open the website. Says page not found. I'm interested in reading it since I will be starting Biotin soon. My neuro didn't object but didn't no anything about the study but then he's not a MS specialist. Thanks.
User avatar
nellie
Family Elder
 
Posts: 101
Joined: Wed Jul 21, 2010 2:00 pm

Re: VITAMIN B7 FOR PMS

Postby EricDrake » Tue Jul 14, 2015 6:11 am

nellie wrote:Hi Seeva. I can't open the website. Says page not found. I'm interested in reading it since I will be starting Biotin soon. My neuro didn't object but didn't no anything about the study but then he's not a MS specialist. Thanks.


Hi nellie,

If you are not a member already I suggest you to join this group if you want to start biotin:
https://www.facebook.com/groups/BiotinForProgressiveMS/
EricDrake
Family Member
 
Posts: 41
Joined: Sun May 10, 2015 3:04 am

Re: VITAMIN B7 FOR PMS

Postby nellie » Tue Jul 14, 2015 7:05 am

Thanks--Yes I am a member. Appreciate your help though.
User avatar
nellie
Family Elder
 
Posts: 101
Joined: Wed Jul 21, 2010 2:00 pm

Re: VITAMIN B7 FOR PMS

Postby ElliotB » Tue Jul 14, 2015 2:47 pm

Biotin's maximum suggest dose varies depends on who you ask. 3mg is not necessarily considered a high dose. Most retail tablets/capsules available are commonly available in doses up to 5mg or 10mg per day. The study done in France which has received a lot of publicity lately provided those in the trial with dosages of 300mg per day. I suggest you do additional research and consider taking more based on your research. Although perhaps you meant 300mg and your 3.00mg is a typo?

As you are aware, you will find a lot of information on Biotin here on TIMS at:

biotin-cerenday-md1003-f56/

It is also probably a good idea to supplement with a B-Complex, a good multi and many other vitamins/supplements including but not limited to D3 and a quality Omega 3 with EFAs.
ElliotB
Family Elder
 
Posts: 1232
Joined: Mon Feb 03, 2014 4:08 pm

Re: VITAMIN B7 FOR PMS

Postby seeva » Wed Jul 15, 2015 2:45 am

Dear friends sorry for the website cannot open please try now
http://www.mstranslate.com.au/vitamin-b ... essive-ms/
regards
seeva
User avatar
seeva
Family Elder
 
Posts: 453
Joined: Sun Jan 20, 2008 3:00 pm
Location: SYDNEY

Re: VITAMIN B7 FOR PMS

Postby DrGeoff » Wed Jul 15, 2015 8:00 am

ElliotB wrote:Biotin's maximum suggest dose varies depends on who you ask. 3mg is not necessarily considered a high dose. Most retail tablets/capsules available are commonly available in doses up to 5mg or 10mg per day. The study done in France which has received a lot of publicity lately provided those in the trial with dosages of 300mg per day. I suggest you do additional research and consider taking more based on your research. Although perhaps you meant 300mg and your 3.00mg is a typo?


I think Elliot, you are confusing milligrams with micrograms.

The French study administered 3 X 100 mcg daily - thats a total of 300 micrograms. Additionally, you have to consider the strength of the Biotin used (or the purity if you want to think of it that way. The French study used 100% pure. A lot of the readily available Biotin is 1% pure, so you can take a guess as to what fillers are added to make up the bulk.

So, in fact, 300 micrograms of 100% pure really is a high dose.

Anyone who wants to try this (100%) for themselves has two choices:
Buy ready filled 100mcg capsules (I believe Skips Pharmacy are now offering these).
Buy a set of microscales, and buy Biotin powder and sort out the doses for themselves.

One easy way is to buy small bottles of water, dissolve the daily 300 mcg (thats 3mg or 0.3 grams) in the water and sip regularly during the day.
That's an approach that could be called a backyard version of controlled release. (Stops to take a sip).

Geoff
DrGeoff
Family Elder
 
Posts: 194
Joined: Mon Aug 05, 2013 2:44 am

Re: VITAMIN B7 FOR PMS

Postby ElliotB » Wed Jul 15, 2015 10:16 am

"The French study administered 3 X 100 mcg daily"

Where did you get this info from.

From all I have read, the study used 300mg (milligrams) as its daily dose total, not 300 mcg (micrograms) or 3mg. 3 mg is a relatively small dose. You can readily buy Biotin in a variety of doses up to 10mg just about anywhere.


per the study's abstract:

"23 consecutive patients with primary and secondary progressive MS originated from three different French MS reference centers were treated with high doses of biotin (100-300mg/day) from 2 to 36 months (mean=9.2 months). Judgement criteria varied according to clinical presentations and included quantitative and qualitative measures."


Again, keep in mind that 3mg of Biotin is not a high dose. And whether you are using pure or not is irrelevant, the dose is the dose, a product with fillers that advertises 10mg of Biotin has 10mg of Biotin plus the filler.

The good thing about Biotin is that if you take more than your body can use/absorb, the excess is eliminated.

MedDay's own website also confirms the 300mg (not 300 mcg) dosage:

http://www.medday-pharma.com/news-and-e ... sclerosis/

"a highly-concentrated pharmaceutical-grade biotin administered at a dose of 300 mg per day"
ElliotB
Family Elder
 
Posts: 1232
Joined: Mon Feb 03, 2014 4:08 pm

Re: VITAMIN B7 FOR PMS

Postby tzootsi » Wed Jul 15, 2015 6:04 pm

There are now hundreds of people taking the recommended 300 mg a day - go to the 'biotin for progressive MS' facebook page for tons of info and feedback. 100% pure biotin is readily available on the internet, as are the scales you need to weigh out a dose.
User avatar
tzootsi
Family Elder
 
Posts: 446
Joined: Sun Nov 22, 2009 3:00 pm

Re: VITAMIN B7 FOR PMS

Postby DrGeoff » Thu Jul 16, 2015 4:26 am

ElliotB is right on the dose, and I am wrong.
I went back through my data and found where my error had come from (a typo in something I had been sent) but this does not excuse my failing to read the abstract again before rushing into print.

I do agree with Elliot that a dose is a dose is a dose ...
But, purity does matter. The volume of material is 100 times larger when dealing with 1% pure than it is when handling 100% pure.
To get the 300mg with 1% pure would mean a dose of three grams. This could pose a problem for thos who dissolve the daily dose in water if the added fillers do not dissolve readily.
Geoff
DrGeoff
Family Elder
 
Posts: 194
Joined: Mon Aug 05, 2013 2:44 am

Re: VITAMIN B7 FOR PMS

Postby 1eye » Thu Jul 30, 2015 11:20 am

Note: The title of this thread says "PMS". I assume that means progressive multiple sclerosis, and not pre-menstrual syndrome. None of the following is to be interpreted as advice, assistance, or medical in any way, shape or form. Let me initiate a discussion, now that 100 days have passed and I've tried again to use my 100 capsule filling machine. Buying caps from Skip Lens's compounding pharmacy at this point, would solve all compounding problems, and they're not that expensive. Also, due to my condition I need help, as I have not got enough manual dexterity.

I have opted to continue using the 100 capsule filling machine. I suspect it's optimal if and only if:

1. you tamp the same amount for each capsule
2. you fill and tamp so that the powder goes all the way to the top of the long half of each capsule

The 100 cap machine I got seems to work more reliably with "00"-size caps. The machine has a spring-loaded section which accommodates the long halves of the capsules, but it must be adjusted using the screw adjustments on the loading springs so that, using the spreader, you can just feel the top 1/2 mm or so of the open end of the capsule, as you brush past them with the spreader. Count the number of times you turn each of the 4 screws, and make sure they're all equally adjusted.

Having said this, it seems I need more than 30 grams (100 doses of 300 milligrams each) of 100% biotin powder, to fill 100 size "00" caps to the top of the open long halves of the capsules. So, my current plan (to be used for the next batch of 100 capsules) is to use 50% filler (probably cellulose) to extend the powder. I will, for each 30 grams of 100 % biotin powder, add another 30 grams of cellulose filler or whatever amount is required to have approximately the same volume as the 100 % biotin powder. It needs to be well-mixed, perhaps with a flour sifter.

That should be enough, with some tamping, to fill up all 100 of the long halves of these 100 "00"-size capsules. I will do that, using enough tamping to fill all 100, and then weigh one. As I do each time, I will use the scale's TARE function to zero it with an empty capsule, and then weigh the full one. It should have approximately 600 milligrams of powder in it, which is 50% biotin powder, for a total of 300mg of 100% biotin in one capsule. The ratio of biotin to cellulose weight may vary depending on the cellulose powder's weight-to-volume (powder density), and how it compares to the raw biotin powder. The two powders are intended to consume equal volumes.

I will still be taking one capsule a day with 300 mg of biotin. As of today I have taken it for about 100 days. This duration may be already longer than the typical period of placebo effect. After I use up all my 250g of biotin, I hope to be using something from a pharmacy, with a doctor's prescription, but as of now I do not have any medical assistance for using biotin. It is all do-it-yourself.
This unit of entertainment not brought to you by FREMULON.
Not a doctor.
User avatar
1eye
Family Elder
 
Posts: 3703
Joined: Wed Mar 17, 2010 3:00 pm
Location: Kanata, Ontario, Canada

Re: VITAMIN B7 FOR PMS

Postby CureOrBust » Thu Jul 30, 2015 6:07 pm

1eye wrote:I have opted to continue using the 100 capsule filling machine. I suspect it's optimal if and only if:

1. you tamp the same amount for each capsule
2. you fill and tamp so that the powder goes all the way to the top of the long half of each capsule

If you use a filler, such that a full capsule contains 100mg, it is acceptably accurate. This is what the professionals do (ie compounding pharmacies).
User avatar
CureOrBust
Family Elder
 
Posts: 3341
Joined: Wed Jul 27, 2005 2:00 pm
Location: Sydney, Australia

Re: VITAMIN B7 FOR PMS

Postby Anunymouse » Tue Nov 10, 2015 12:16 pm

You just need to be close, not exact. Even if the dose in the pill was exact, the dose in your body isn't. That is if you weigh 100lbs and the guy next to you 300lbs and the 'dose' is the same with no adjustment for body weight, he's taking 1/3 the dose to get the same results (by body mass). None of the testing on anything has more than a childs and an adults dosage schedule. Since we're not all identical, logic says just be in the ballpark and life is good.
Anunymouse
Family Member
 
Posts: 54
Joined: Thu Sep 04, 2014 10:07 pm

Re: VITAMIN B7 FOR PMS

Postby CureOrBust » Tue Nov 10, 2015 9:10 pm

Anunymouse wrote:You just need to be close, not exact. Even if the dose in the pill was exact, the dose in your body isn't. That is if you weigh 100lbs and the guy next to you 300lbs and the 'dose' is the same with no adjustment for body weight, he's taking 1/3 the dose to get the same results (by body mass). None of the testing on anything has more than a childs and an adults dosage schedule. Since we're not all identical, logic says just be in the ballpark and life is good.
I agree with you. On a side note, I remember reading somewhere that dosing of medication is better based on "skin surface area" and not weight. Impractical in most cases, so even researches use a weight factor for simplicity.
User avatar
CureOrBust
Family Elder
 
Posts: 3341
Joined: Wed Jul 27, 2005 2:00 pm
Location: Sydney, Australia


Return to Biotin (Qizenday, Cerenday, MD1003)

 


  • Related topics
    Replies
    Views
    Last post

Who is online

Users browsing this forum: No registered users


Contact us | Terms of Service