Findings, published in the Journal of Neuroinflammation, showed that lactate was higher in the cerebrospinal fluid of patients than in controls. Moreover, the levels were higher in those with longer disease duration. High lactate levels in MS patients were also linked to disease severity ...
...These findings point to the possibility of a link between energy metabolism and MS severity. The authors speculated that such an association could be, in part, dependent on the increased energy demands of neurons that have lost their protective myelin coating. This increased stress on the neuronal energy production system could, in itself, lead to mitochondrial damage.
Study findings imply that pursuing therapies targeting mitochondrial injury could prevent disease progression and the accumulation of disability in RRMS patients.
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