i don't think my jimmylegs were RLS exactly.. if the descriptions of RLS are spot on, i had something else. however, i have read that low iron can be a cause of RLS. also, magnesium. further, there have been connections made between low iron and low B12 in MS patients. absolutely useless n in the following abstract, but it's something:
Quote:
Iron and the folate-vitamin B12-methylation pathway in multiple sclerosis
Journal Metabolic Brain Disease
Issue Volume 21, Numbers 2-3 / September, 2006
Iron and the folate-vitamin B12-methylation pathway in multiple sclerosis
Abstract Some subjects with multiple sclerosis (MS) present with low blood iron parameters. Anecdotal reports and a single patient study suggest that iron supplementation may be beneficial in these subjects. Myelin is regenerated continually, but prerequisites for this process are iron and a functional folate-vitamin B12-methylation pathway. The aim of this study was to determine iron status, folate and homocysteine in MS subjects, and to evaluate the effect on MS symptoms if deficiencies were addressed. Results: In relapsing-remitting MS subjects, serum iron concentration correlated significantly with age at diagnosis (r=0.49; p=0.008). In Caucasian female MS subjects, serum iron and ferritin concentrations were significantly lower than in matched controls. In a 6-month pilot study, 12 subjects taking a regimen of nutritional supplements designed to promote myelin regeneration, improved significantly neurologically as measured by the Kurzke EDSS (Total Score means 3.50 to 2.45, 29.9%; p=0.021). These were significantly improved (p=0.002) compared to 6 control group patients taking multivitamins (Kurzke Score increased by 13.9% from 4.83 to 5.50). Both groups had significantly reduced homocysteine concentrations at 6 months, suggesting that methylation is necessary but not sufficient for myelin regeneration.
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