Interesting Gauchito. We are looking at the effects of excess iron over on the "phlebotomy anyone" thread.
Hemosideran is of course part of the iron metabolism. And it has some connection to Porphyrins. So Zamboni is on to it in one connection. Good!
Maybe some in depth gene studies on people with MS, looking at hemochromatosis genes and Porphyria Genes would be incredibly interesting.
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Hemosiderin image of a kidney viewed under a microscope. The brown areas represent hemosiderin
Heme. Iron is at center.Hemosiderin or haemosiderin is an iron-storage complex. It is always found within cells (as opposed to circulating in blood) and appears to be a complex of ferritin, denatured ferritin and other material. The iron within deposits of hemosiderin is very poorly available to supply iron when needed.
Several disease processes result in deposition of larger amounts of hemosiderin in tissues; although these deposits often cause no symptoms, they can lead to organ damage.
Hemosiderin is most commonly found in macrophages and is especially abundant in situations following hemorrhage, suggesting that its formation may be related to phagocytosis of red blood cells and hemoglobin. Hemosiderin can accumulate in different organs in various diseases.
Iron is required by many of the chemical reactions (i.e. oxidation-reduction reactions) in the body but is toxic when not properly contained. Thus, many methods of iron storage have developed.
Hemosiderin often forms after bleeding (hemorrhage). When blood leaves a ruptured blood vessel, the cell dies and the hemoglobin of the red blood cells is released into the extracellular space. White blood cells called macrophages engulf (phagocytose) the hemoglobin to degrade it, producing hemosiderin and porphyrin.
 Diseases associated with hemosiderin deposition
Main article: Hemosiderosis
Hemosiderin may deposit in diseases associated with iron overload. These diseases are typically diseases in which chronic blood loss requires frequent blood transfusions, such as sickle cell anemia and thalassemia.