The fact that so many more MS patients had the condition is a significant finding, said Dr. Zivadinov. He also noted, however, that the vein narrowing was more common in people at more advanced stages of the disease.
"That would be against CCSVI being a primary cause of MS, although clearly this can't be determined yet," said Dr. Zivadinov. "This will be very difficult to determine: what is the chicken and what is the egg."
No, I think this makes a lot of sense. Zamboni's study did not show this difference, where ccsvi is correlated with more advanced forms of m.s. Zivadinov turned up that difference (38% CIS, 80% more advanced m.s.) but has been cautioning that we don't know how to interpret that yet. It could point to CCSVI getting worse as a result of m.s. It could point to CCSVI progressing as m.s. progresses (and simply as age progresses); this is what I suspect. It could indicate that you might get m.s. from some other cause but that if you also have ccsvi you'll have a more advanced case of m.s. It is not clear cut, but only because it's opened up a box full of questions, not because of confusion, in my opinion.
I think one reason to include CISers is because of a belief that CCSVI is congenital and that it would show up in them even if it hadn't caused really bad m.s. yet. It is unexpected that it didn't.