Until the actual data are published, everything is speculative, but there is the additional information
from Fiddler about the Canadian Press medical reporter interview
with Dr. Zivadinov in which he is reported to have said that 80% of the CDMS group were found to have CCSVI while only 38% of the CIS group were CCSVI positive.
Since roughly 40% of the CIS group had CCSVI and half of people with CIS can be expected to progress to full blown MS, that, assuming it is the people with CCSVI who progress to full blown MS, means that 80% of those with CIS who go on to full MS have CCSVI. That's pure assumption because we don't know yet who among the CIS group has CCSVI nor who will develop full MS, but it seems like a valid working hypothesis that should be tested in further research.
When you then correct the above numbers for (1) possible error in the diagnosis of MS as well as (2) the use of close relatives who have an extremely high chance of developing MS in the control group, I think you end up with something very close to what Dr. Zamboni has reported where he says that with 100% sensitivity and specificity as well as predictability, you can identify people with MS by whether they have CCSVI.
That points to a single explanation for MS, though there are probably both environmental and genetic factors that may further complicate the damage done by CCSVI, the rate at which it progresses and so on.
In other words, the 22% of controls shown to have CCSVI may well be undiagnosed, early cases of MS given that close relatives have such a high probability of developing MS. So rather than undermining the link between CCSVI and MS, it may well support it and provide a path to early diagnosis of MS.
Just to put all the data in one place, here's some additional information on the study from Dr. Zivadinov's presentation at Hamilton
50 Pediatric MS
50 RIS (Radiologically Isolated Syndrome)
300 "Adult Healthy and Familial Controls"
50 "Pediatric Healthy and Familial Controls"
150 CNS Autoimmune Disorders (SLE, PLAP, Vascular)
50 CNS Other Neurodegenerative Disorders (AD, PD, Epilepsy)
None of this speaks to any of our questions about the break down of the first 500 patients, although it does seem to make clear that the "Healthy Controls" are in fact familial which I think adds a twist to the findings as far as the controls since we know the probability of family members developing MS is very high.