biogen and ccsvi

A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.

biogen and ccsvi

Postby sbr487 » Fri Feb 19, 2010 10:37 am

So finally the world is waking up to ccsvi ...

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Postby markus77 » Fri Feb 19, 2010 10:42 am

they are trying desperately to hide CCSVI but they hear the thunder in the distance.....
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Postby NewHope » Fri Feb 19, 2010 12:41 pm

It won't be long before Biogen and Teva stocks sink! I'd suggest that their investors look around and realize that CCSVI is a revolutionary breakthrough discovery that will forever change the way MS is diagnosed and treated!!! Their investors must seriously consider selling. Only little research is needed to show them their money is in danger!
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Postby Vonna » Fri Feb 19, 2010 1:39 pm

Hi Sbr,

A few days ago, I went to the BIIB (Biogen) message board, and there was absolutely NOTHING about CCSVI. I searched the message board and found one lone post from back on Nov. 9, with no replies. I commented and asked others to join me. Slowly, it is picking up speed.

Can you believe it? Their stocks are still gaining, even after the 4 new cases of PML a few days ago! I'm watching the stock on the CCSVI Worldwide Victory website here.

http://ccsvivictory.club.officelive.com/Biogen.aspx

Down toward the bottom of the page.
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Postby fernando » Fri Feb 19, 2010 1:48 pm

Billions of dollars at stake. What would they do to preserve their benefits? We are talking not about only one drug but an entire industry.

Maybe they can learn something from Tobacco companies.

Ok. Now someone will call me paranoid.
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Postby SammyJo » Fri Feb 19, 2010 3:10 pm

Here is the post on the WSJ article, that totally missed CCSVI, so I asked everybody to send the reporters emails and comments, and I've since heard WSJ is working on a CCSVI story. Feel free to ping them again with the Biogen info, their emails are at the end of the story.

http://www.thisisms.com/ftopict-9819-wa ... et+journal

Here is a nice summary on MS drug market, but from 2007
http://www.wikinvest.com/concept/Multiple_Sclerosis_(MS)_Drug_Market
RRMS '95 SPMS '02 | CCSVI 10/09 | Adult stem cells 2012 | http://www.patientsforstemcells.org/
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Postby markus77 » Fri Feb 19, 2010 7:16 pm

it looks like since fall the biogen stock prices have been rising almost like its been pushed up on purpose. hmmmm. theres a coincedence. looks like its peaking and judging by the past its about time it will tank. this time it will not stop tanking. HAHA

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Postby sbr487 » Fri Feb 19, 2010 8:58 pm

Hope the investor pressure will keep biogen (and other pharmas) so busy that they will not have energy to carry out anti ccsvi campaign. And ccsvi supporters can start breathing again ...
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Postby Vonna » Fri Feb 19, 2010 11:33 pm

Feb. 9, 2010
Biogen Conference Call With Investors

It's about an hour long, so I'll give you a few highlights.

http://snipurl.com/ugqu5

One reason stock went up so drastically is because Biogen had to buy back it's own stock! (After news of PML) They have 100,000,000-I believe in the conference call they said they had one hundred million set aside at any given time to invest inwardly or outwardly. I might be wrong, but this is what stuck in my head.


*Four new employees were announced. One from BNAC (just before CCSVI study results were announced), one from NMSS and his wife just days after that.

*The call referred several times to how benefits outweigh the risks of PML, and how they intend to use this as a marketing strategy.

-However, more and more cases are showing up, in rapid succession. This is because the risk increases the longer you take Tysabri! Those that are developing PML are mostly those that have been on it 2-3 years. Biogen admits, they really don't know the risks after this, it really hasn't been studied!

*At the end of the call, there is a question and answer session in which a caller asks three questions. It starts on minute 40, if you want to skip forward, you don't have to hear the whole call. His questions were concerning the PML trials that were going to take place. Funny how they are allowed to keep their deadly drug on the market while conducting safety trials of it.

*The questions were about what the study would measure and how. Right away, the guy answering started stuttering. He stumbled and stuttered the entire time, not making complete sentences and not answering one of the guys questions. The guy wanted to know if they were just going to test everyone in the beginning, and then see who developed PML, or what.

*So, what I could make out is, they do blood tests, and save it, wait for people to develop PML and then compare the stored blood with a fresh urine sample. It was really hard to understand.

Here's the really rough unedited transcript I just tried to type as I listened:

What is the design of the study for potential drop outs who turn out to have a high risk factor?

Well, I mean, uh, uh, as you point out, the denominator may change-in terms of these two strata-But if the the uh uh if the risk decreases in a num… then we should see iiiiif if if Most of the people are in a low risk category the overall risk of PML should go down. And a number of cases should go away. Or dis, or or diminish so if that’s the case then we will have answered the question. I think the denominator will need to be adjusted uuumm according to the number of people that stay in the in the strata that uh, that we’re studying.

And what is the design of the study? And what will you specifically be measuring?

E uh uh if we’re talking about the uh seriological accates it is basically simply a blood draw. Where we take the blood, store it, and we we actually have a couple of studies and one study we will verify that the findings we got from our strata samples is is the same. Uh, we will match it up urine JC virus in the other study we will collect blood and see whether or not when patients develop PML they were antibody positive, at that prior timepoint, or not.

Is it just the antibody or what are the JC virus specific T-Cell function assays or the viral protein assays that you will also monitoring and do you normally check those if the patients are positive or do you test everyone and then see who gets PML?

Thu Thu those those will be separate studies done uh in a focused way uh in conjunction with some registries and other studies going on in Europe and elsewhere where we will look for additional uhhh biomarkers. Uh, they will include cellular assates such as you indicate uh, that test immune response. Ummm, they’ll they’ll also look for mutation in JC virus Uhh, if we get a technology that we can use to measure mutation Uh, and so forth, but there are some studies that are uh, uh,, that are going to be underway uh, for example in Germany, and we we intend to collaborate with the investigators who are doing those studies.



I couldn't help but laugh, but this is really far from funny.
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Postby Johnson » Fri Feb 19, 2010 11:50 pm

And a number of cases should go away.


Yikes!

How will they go away? I shudder to think.

Vonna, you are a star.
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Postby Vonna » Sat Feb 20, 2010 12:00 am

Sounds like what he is trying to say without saying it is that they will cull out the ones with high risk for PML and they will not be included in the study, that way, the numbers look good.
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Postby Loobie » Sat Feb 20, 2010 8:47 am

That's exactly what they did with Avonex.
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Postby Vonna » Sat Feb 20, 2010 6:57 pm

The Biogen board is starting to liven up a little!

http://messages.finance.yahoo.com/Stock ... ew?bn=9159

Loobie, do you have any references for what you said about Tysabri?

I believe you, would just like to have any reference you might have.
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Postby cah » Sun Feb 21, 2010 1:03 am

Here are the commercial figures and plans from biogen for 2010:

http://webcastingplayer.corporate-ir.ne ... ID=2683499

but be sure to buy some of these first:

Image
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Postby cah » Sun Feb 21, 2010 4:21 am

Here's more:

http://www.sec.gov/Archives/edgar/data/ ... efa14a.htm

really makes me sick. Esp. page 8.
"There is only one good, knowledge, and one evil, ignorance." Socrates
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