Zivadinov Hamilton presentation

MS_mama · Post by **MS_mama** » Tue Feb 23, 2010 8:29 pm

On slide 25 of Zivadinov's Hamilton presentation, he describes the different study groups. Under the MS group he has listed 500 RRMS, 300 SPMS, 50 PPMS, and 50 NMO.

So is NMO considered a sub-group of MS? I thought it was different, one of the differential dx'es of MS-- they don't take the CRAB meds and instead use intense immune suppression such as Imuran, etc. Am I mistaken, or is there some reason that they would be included in the CDMS group?

danegirl · Post by **danegirl** » Tue Feb 23, 2010 11:09 pm

What is NMO???

Algis · Post by **Algis** » Tue Feb 23, 2010 11:45 pm

optical neuritis (NeuroMyelitis optica)

costumenastional · Post by **costumenastional** » Wed Feb 24, 2010 1:52 am

If i had to guess i d say that they included NMO to find out if is just another way of the immune system to react to ccsvi. Can you imagine how huge it would be to link other demyelinating diseases to ccsvi?

frodo · Post by **frodo** » Wed Feb 24, 2010 3:25 am

MS_mama wrote:On slide 25 of Zivadinov's Hamilton presentation, he describes the different study groups. Under the MS group he has listed 500 RRMS, 300 SPMS, 50 PPMS, and 50 NMO.

So is NMO considered a sub-group of MS? I thought it was different, one of the differential dx'es of MS-- they don't take the CRAB meds and instead use intense immune suppression such as Imuran, etc. Am I mistaken, or is there some reason that they would be included in the CDMS group?

I would say that they are trying to prevent critics, making some kind of devil's advocate game. The whole trial rules are design so that they get lower success than what they should get. Things like to consider CIS inside the MS group (which it seems they did) are not normal in any trial. Let alone NMO.

By the way, aren't these numbers too high? It was expected that the whole trial would have around 1000 people among all the groups, and here we have 900 with MS and variants. Where are the OND and controls?

MSUK · Post by **MSUK** » Wed Feb 24, 2010 3:30 am

danegirl wrote:What is NMO???

Devic's Disease - http://www.msrc.co.uk/index.cfm/fuseact ... ageid/1643

Billmeik · Post by **Billmeik** » Wed Feb 24, 2010 8:07 am

can someone include a link to this talk or notes on it?

MSUK · Post by **MSUK** » Wed Feb 24, 2010 8:24 am

Billmeik wrote:can someone include a link to this talk or notes on it?

They are all here : http://www.msrc.co.uk/index.cfm?fuseact ... ageid=2955

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Zivadinov Hamilton presentation

Zivadinov Hamilton presentation

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