Zivadinov Hamilton presentation

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Zivadinov Hamilton presentation

Postby MS_mama » Tue Feb 23, 2010 9:29 pm

On slide 25 of Zivadinov's Hamilton presentation, he describes the different study groups. Under the MS group he has listed 500 RRMS, 300 SPMS, 50 PPMS, and 50 NMO.

So is NMO considered a sub-group of MS? I thought it was different, one of the differential dx'es of MS-- they don't take the CRAB meds and instead use intense immune suppression such as Imuran, etc. Am I mistaken, or is there some reason that they would be included in the CDMS group?
dx RRMS Jun. 2009...on Copaxone and LDN and waiting for my turn to be "liberated"<br />
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Postby danegirl » Wed Feb 24, 2010 12:09 am

What is NMO???
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Postby Algis » Wed Feb 24, 2010 12:45 am

optical neuritis (NeuroMyelitis optica)
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Postby costumenastional » Wed Feb 24, 2010 2:52 am

If i had to guess i d say that they included NMO to find out if is just another way of the immune system to react to ccsvi. Can you imagine how huge it would be to link other demyelinating diseases to ccsvi?
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Re: Zivadinov Hamilton presentation

Postby frodo » Wed Feb 24, 2010 4:25 am

MS_mama wrote:On slide 25 of Zivadinov's Hamilton presentation, he describes the different study groups. Under the MS group he has listed 500 RRMS, 300 SPMS, 50 PPMS, and 50 NMO.

So is NMO considered a sub-group of MS? I thought it was different, one of the differential dx'es of MS-- they don't take the CRAB meds and instead use intense immune suppression such as Imuran, etc. Am I mistaken, or is there some reason that they would be included in the CDMS group?


I would say that they are trying to prevent critics, making some kind of devil's advocate game. The whole trial rules are design so that they get lower success than what they should get. Things like to consider CIS inside the MS group (which it seems they did) are not normal in any trial. Let alone NMO.

By the way, aren't these numbers too high? It was expected that the whole trial would have around 1000 people among all the groups, and here we have 900 with MS and variants. Where are the OND and controls?
Last edited by frodo on Wed Feb 24, 2010 4:53 am, edited 1 time in total.
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Postby MSUK » Wed Feb 24, 2010 4:30 am

danegirl wrote:What is NMO???


Devic's Disease - http://www.msrc.co.uk/index.cfm/fuseact ... ageid/1643
MS-UK - http://www.ms-uk.org/
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Postby Billmeik » Wed Feb 24, 2010 9:07 am

can someone include a link to this talk or notes on it?
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Postby MSUK » Wed Feb 24, 2010 9:24 am

Billmeik wrote:can someone include a link to this talk or notes on it?


They are all here : http://www.msrc.co.uk/index.cfm?fuseact ... ageid=2955

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