HIV, HHV,... stenosis ?

A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.

HIV, HHV,... stenosis ?

Postby ttt1 » Wed Mar 03, 2010 6:15 am

some high load viruses can cause stenosis

"The CT angiography revealed coronary atherosclerosis in 59 percent of the HIV-infected patients, compared with only 34 percent of controls."
http://www.harvardscience.harvard.edu/m ... tudy-finds

Herpes virus implicated in clogging of arteries, November 1986
http://www.nytimes.com/1986/11/18/scien ... eries.html
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Postby Algis » Wed Mar 03, 2010 6:31 am

Those are arteries. Does it apply to veins?
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Postby cheerleader » Wed Mar 03, 2010 9:05 am

Dr. Zamboni's team is studying how viruses such as EBV can contribute to severity of stenosis as endothelial disrupters. Viruses could potentially create worse reflux and occlusion in certain MS patients...more studies ahead.
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Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
http://ccsviinms.blogspot.com
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Postby Cece » Wed Mar 03, 2010 11:14 am

Just googling endothelial disruption turns up some interesting articles.

"Blood-brain barrier disruption in multiple sclerosis"

http://msj.sagepub.com/cgi/content/short/9/6/540?rss=1&ssource=mfc

"Exposure of endothelium to proinflammatory cytokines (IFN-g, TNF-a and IL-1b) interrupts the BBB by disorganizing cell-cell junctions, decreases the brain solute barrier, enhances leukocyte endothelial adhesion and migration as well as increases expression of class II MHC and promotes shedding of endothelial ‘microparticles’ (EMP). In this review we examine interactions between cytokines/chemokines, activated leukocytes, adhesion molecules and activated C EC in the pathogenesis of BBB failure in MS."

This is from 2003, without the CCSVI paradigm but looking at the vascular side of m.s. Again those adhesion molecules are mentioned. I am assuming proinflammatory cytokines would be what the body makes in response to viruses in general.
"However, the truth in science ultimately emerges, although sometimes it takes a very long time," Arthur Silverstein, Autoimmunity: A History of the Early Struggle for Recognition
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