do not forget that Flagyl is also a neuro-toxic, so the "something happening" may not be "die-off".NZer1 wrote:If antibiotics change the symptoms and increase the symptoms then there is something else happening.
There is a die off effect, an endo-toxin release or a Herxheimer effect happening and that is a clue that there is a combination or multi faceted puzzle with MS.
MarkW wrote:drsclafani wrote:Look at it this way.
There are symptoms that are commonly the result of CCSVI. These include chronic fatigue, cog fog, memory impairment, vision difficulties, imbalance and autonomic problems such as bladder problems (urgency, frequency, nocturia, hesitancy), purple feet and edema, and heat intolerance. To a much lesser degree, motor function, sensory problems,
These are symptoms commonly seen with MS: motor problems, with spasticity, sensory problems numbness and tingling, vision problems, cerebellar problems such as ataxia, imbalance, cranial nerve problems, chronic fatigue, cog fog, memory impairment, vision difficulties, imbalance and autonomic problems such as bladder problems (urgency, frequency, nocturia, hesitancy), purple feet and edema, and heat intolerance. To a much lesser degree, motor function, sensory problems,
So you see that symptoms of ccsvi and ms overlap. We can treat the ccsvi and have no significant clinical change if the symptoms were caused by MS.But if the symptoms were caused by CCSVI , treating the CCSVI can improve symptoms.
I have said all along that I treat CCSVI not MS. I wish it were simpler but I wont know for ten years whether treating CCSVI alters outcomes of MS
That being said, i recently have had two patients with severe spasticity which I believed were clearly due to demyelinization. To my surprise some improvements occurred after venoplasty. I still cannot figure out why this occurs.
You said that you cannot figure out why improvements in spasticity occurs after venoplasty. I suggest that the areas between 'CCSVI symptoms' and 'MS symptoms' have a large area of overlap. There are 'CCSVI symptoms' which could be considered as the result of reduced CSF flow and 'MS symptoms' which are the result of myelin (WM) damage. However there are reports of GM repair after venoplasty, any thoughts where they should be placed?
Also venoplasty could reduce compression on the vagus nerve, which may explain some improvements. Some venoplasty may reduce compression on other cranial nerves, as yet not considered in detail.
Here in Oxford there are two of us who are experiencing slow (months to years) improvements in spasticity, post venoplasty.
I am unsure what the mechanism could be, but I keep in mind that the human body tries to return to its steady state position (repair itself) when damage is stopped. Any thoughts?
I agree that we won't know for years whether treating CCSVI alters MS. I am hoping that after 5 years I will know if my spending on two venoplasties was a good bet or not.
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