Nunzio wrote:I always had a problem with MS being autoimmune because Myelin cover our nerves throughout our entire body except the inside of the eye but in MS the attack is only against the brain which is protected by the Blood Brain Barrier(BBB). It would make more sense if MS would attach our nerve in other parts of our body and spare our brain because of the BBB.
CCSVI cause damage to the nerves by accumulation of toxins or possibly iron and then the immune system comes in to clean up the mess.
Just a thought
Myelin oligodendrocyte glycoprotein (MOG) is one of the immune targets in MS.
Myelin oligodendrocyte glycoprotein (MOG) is thought to be one of the immune targets in MS.
Multiple sclerosis: distribution of inflammatory cells in newly forming lesions.
INTERPRETATION: Early loss of oligodendrocytes is a prominent feature in tissue bordering rapidly expanding MS lesions. Macrophage activity is largely an innate scavenging response to the presence of degenerate and dead myelin. Adaptive immune activity involving T and B cells is conspicuous chiefly in recently demyelinated tissue, which may show signs of oligodendrocyte regeneration. The findings suggest that plaque formation has some basis other than destructive cell-mediated immunity directed against a myelin or oligodendrocyte antigen.
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