Important ..the link we have been looking for????

A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.

Important ..the link we have been looking for????

Postby Brightspot » Fri Mar 26, 2010 9:51 pm

someone forwarded this to me today..looks like some really helpful results from Buffalo. Lots of studies results (abstracts) listed. This is my personal favourite! It seems to say quite clearly that CCSVI indicates compromised oxygenation of the brain.

American Academy of Neurology (AAN) Annual Meeting, Toronto, 10–17 Apr 2010.
Last modified: 23.03.2010 - 22:45 CET Created: 23.03.2010 - simplex
There is soon the big neurology meeting: American Academy of Neurology (AAN) Annual Meeting 2010. Toronto, 10–17 Apr 2010. [aan10a]

Presentations covering CCSVI

OBJECTIVE: To investigate the relationship between chronic cerebrospinal venous insufficiency (CCSVI) and cerebral perfusion in patients with multiple sclerosis (MS). BACKGROUND: CCSVI is a vascular condition described in MS patients, characterized by stenoses of the main extracranial veins with hampered cerebral venous outflow. We hypothesized that the impaired venous outflow contributes to hypoperfusion of brain parenchyma. DESIGN/METHODS: Sixteen consecutive relapsing-remitting MS patients (mean age 36.1yrs, mean disease duration 7.5yrs and median EDSS 2.5) and 8 age- and sex-matched normal controls (NC), were scanned on a GE 3T scanner using dynamic susceptibility contrast enhanced perfusion-weighted imaging (PWI). Cerebral blood flow (CBF), blood volume (CBV) and mean transit time (MTT) were measured in the gray matter (GM), white matter (WM), normal appearing (NA) GM, NAWM, thalamus, caudate, putamen, globus pallidus, hippocampus, amygdala, nucleus accumbens, red nucleus and substantia nigra. Diagnosis of CCSVI was established based on the venous hemodynamic (VH) Doppler criteria (Zamboni, JNNP, 2009) and the severity was based on fulfilled VH criteria (score 0-5) and VH insufficiency severity score (VHISS) (score 0-16). RESULTS: All 16 MS patients fulfilled the diagnosis of CCSVI (median VH=4, median VHISS=9) and none of the NC. There was a significant association between VH criteria and VHISS, and CBF, CBV and MTT in all examined regions of the brain parenchyma in MS patients. The most robust correlations were observed for lower CBF and higher VHISS in the GM, WM, NAGM and NAWM (r= -0.70 to -0.72, p<0.002), and in the thalamus, caudate, putamen, hippocampus, nucleus accumbens (r= -0.6 to -0.72, p<0.008). The correlation coefficients for CBV and MTT were in a range between r= -0.5 to -0.65. No relationship was observed for NC. CONCLUSIONS/RELEVANCE: This study demonstrates that severity of CCSVI is directly associated with hypoperfusion of the brain parenchyma in MS. Supported by: Hillarescere Foundation and Buffalo Neuroimaging Analysis Center.

Category - MS and Related Diseases - Clinical Science
Wednesday, April 14, 2010 7:30 AM
Poster Session III: Multiple Sclerosis and Related Diseases: MRI/Technique (7:30 AM-12:00 PM)
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Postby PCakes » Fri Mar 26, 2010 10:13 pm

incredible! by participant numbers small results..HUGE!! don't know how you got this but !!
p.s. i spent an hour working on a piece to send you only to have it lost in cyberspace..aaaargh.. everything happens for a reason..must have been really bad :)
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Postby SoberSandy » Fri Mar 26, 2010 10:45 pm

Here is some more and more to come.
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Postby Algis » Fri Mar 26, 2010 10:45 pm

RESULTS: All 16 MS patients fulfilled the diagnosis of CCSVI (median VH=4, median VHISS=9) and none of the NC

not bad...
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Postby muse » Fri Mar 26, 2010 10:45 pm

PCakes wrote: don't know how you got this but !!

That's one source of the real source. ;)
Arne http:/// ... 7-apr-2010
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Postby SoberSandy » Fri Mar 26, 2010 11:50 pm

More to read regarding MS and CCSVI
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Postby frodo » Sat Mar 27, 2010 4:05 am

Algis wrote:
RESULTS: All 16 MS patients fulfilled the diagnosis of CCSVI (median VH=4, median VHISS=9) and none of the NC

not bad...

Probably this means that the participants were selected so that they had MS and fulfilled the CCSVI requirements. No conclusions can be extracted from here.
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Research filtering out

Postby MarkW » Sat Mar 27, 2010 5:14 am

Hello Brightspot,
Thanks for reminding the CCSVI chatroom of the AAN April meeting. The abstracts are a typical scientific way of sharing information. Snippets of research are presented which need to be pieced together.
I hope that by the end of the AAN meeting that the correlation between CCSVI and MS is demonstrated in a large study. Then abstracts like the ones posted on justify why the symptom CCSVI should be treated. Muse/Arne already posted the link: ... 7-apr-2010
It is not a complete story about CCSVI and MS but scientific journal reporting does not work like that, which I realise is frustrating for pwMS and their carers.

Kind regards,
Mark Walker - Oxfordshire, England. Retired Pharmacist. 16 years of study about MS.
CCSVI Comments:
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Postby Nunzio » Sat Mar 27, 2010 5:35 pm

let me translate this for you.
The study was not to demonstrate that MS is associated with CCSVI. This is already estabilished but to clarify if CCSVI had an effect on the brain.
They took 16 consecutive MS patients and 8 control.
It jusy so happened that all MS patients had CCSVI and none of the control did,but more importantly, the study demonstrated that all MS patients had decrease blood perfusion throughout the tissue of the brain. This is extremely important because shows that CCSVI is not just a coincidental finding but a condition that affect the brain perfusion and as such should be treated.
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Postby ljh » Sat Mar 27, 2010 6:15 pm

thanks, Nunzio- nicely and neatly explained! now the challenge is to convince Governments!
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Postby eric593 » Sat Mar 27, 2010 10:16 pm

Has any of this been added to the 'Research' sticky at the top of the page? Very important to keep the important info in an easily accessible place.

This is quite striking information. Better than mice data. :) I hope the AAN will really add more exciting evidence of an association between CCSVI and health problems. I hope it's not just Buffalo but other investigators that can add to our puzzle.

Very exciting!
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