Problems Resulting From Iron Toxicity
There are many problems that may result from iron toxicity, these include: anorexia, oligura, diarrhea, hypothermia, diphasic shock, metabolic acidosis, and death. In addition to these, the patient may experience vascular congestion of the gastrointestinal tract, liver, kidneys, heart, brain, spleen, adrenals, and thymus.
RESULTS: Twelve of fourteen patients had an increase in iron above normal levels and with a particular pattern of iron deposition in the medial venous drainage system that was associated with the confluence of the veins draining that structure. CONCLUSION: Iron may serve as a biomarker of venous vascular damage in multiple sclerosis. The backward iron accumulation pattern seen in the basal ganglia and thalamus of most MS patients is consistent with the hypothesis of venous hypertension.
mangio wrote:Venous Hypertension I read. Maybe this is why at Hamilton workshop this
was hinted at.
High blood meds, exercise anyone?
cheerleader wrote:Venous hypertension is different than simple hypertension, mangio. It isn't related to arterial output, but rather it is caused by slowed venous drainage creating a backflow and congestion.
Iron has been implicated in multiple sclerosis for many years. It has been observed by MRI and has been seen in vessel wall for small venules. More recent work has shown that there can be iron build up around MS lesions and inside the lesions although not all lesions show an increase in iron content. Further, different parts of the brain associated with the medial venous drainage system also can show increases in iron content that appear to be affiliated with the draining veins. This iron is often not present in MS lesions although in some cases it is and appears as either a uniform intensity or as a ring-like structure around the lesion. Iron in the pulvinar thalamus can increase and is seen in roughly 50% of MS cases especially for young people. It is quite possible these increases in iron are related to the chronic venous insufficiency and may represent iron in one of three forms: oligodendrocyte ferritin after macrophage activity, iron from blood products or iron in the vessel wall or some combination of these. The iron that is measured here may represent hemosiderin which comes from the breakdown of blood not from other sources of iron. There is no evidence at this time that there are stray sources of iron causing this problem, nor has that been proposed in this research. Further, it is unknown what role iron plays at this time and the main effect may remain the demyelinating inflammatory aspects of MS with iron representing either an outcome of endothelial damage or hemosiderin or as part of the inflammatory pathway. Much remains to be learned and it is possible that iron may serve as a biomarker for MS.
Affects 1-2% of population
Due to chronic venous insufficiency and distal vein hypertension
Usually due to post thrombotic syndrome
Can be due to primary valvular incompetence
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