gainsbourg wrote:It's popular these days to assume that MS is simply caused by CCSVI, but if that is so - how do we account for all those herpes antibodies appearing in the CSF during MS attacks? It makes me wonder...
Rokkit wrote:[The International uni0n of Phlebology studied the evidence and voted unanimously to include the venous malformations found in CCSVI in their consensus document and classified the malformations as congenital. So, CCSVI might not cause MS, but MS certainly doesn't cause CCSVI (neither does herpes).
patientx wrote:That's very democratic of the union, but I don't think it really settles what causes stenosis of the extra-cranial veins
PCakes wrote:I am aware that EBV is listed possible as causel or contributing to MS but with 80% (probably closer to 100%) of the populace exposed to and/or carrying EBV by their 4th decade..how can this be singled out?
I read the article by Zivadinov (1) with reference to the association of Epstein-Barr virus (EBV) to gray matter atrophy in multiple sclerosis (MS) patients.
Accumulation of EBV infected B cells in meninges and perivascular regions of MS lesions in 21 or 22 patients with MS (2) was noted as well, indicating direct involvement of the brain and perivascular spaces by EBV in MS patients..
A recent study has indicated chronic cerebrospinal venous insufficiency with multiple extracranial venous strictures in MS patients (3).
EBV appears to infect endothelial cells (4), and may be important in the pathology of EBV virus.
EBV virus has been found to cause deep venous thrombosis in a patient with hereditary thrombophilia (5).
EBV may infect the venous endothelium causing venous thromboses and strictures in the cranial and spinal venous drainage system and perivascular regions of MS lesions in patients with MS.
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