CCSVI and MS progression

A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.

CCSVI and MS progression

Postby Mechanicallyinclined » Fri Apr 02, 2010 10:04 pm

Check out this website and the conclusion of this study.

http://www.neurology.org/cgi/content/ab ... 74/13/1041
Last edited by Mechanicallyinclined on Sat Apr 03, 2010 9:12 am, edited 1 time in total.
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Re: CCSVI and MS progression

Postby bretzke » Sat Apr 03, 2010 2:03 am

Mechanicallyinclined wrote:Check out this website and the conclusion of this study.

http://www.neurology.org/cgi/content/ab ... 74/13/1041

I don't think that a relationship between CCSVI and MS is even a question.


This study found that MS patients with vascular problems progressed more rapidly than those without vascular problems. The "vascular problems" reported were heart disease, high blood pressure, diabetes, high cholesterol and peripheral vascular disease.

The peripheral vascular disease group was considered too small to be significant in the study.(this would be where ccsvi fits)

After reading the entire study, I was less excited about the potential CCSVI-MS link from this study.
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Postby drsclafani » Sat Apr 03, 2010 2:58 am

is study found that MS patients with vascular problems progressed more rapidly than those without vascular problems. The "vascular problems" reported were heart disease, high blood pressure, diabetes, high cholesterol and peripheral vascular disease.

The peripheral vascular disease group was considered too small to be significant in the study.(this would be where ccsvi fits)


This paper did not really consider ccsvi at all. it spoke about vascular disease in the context of atherosclerotic disease and risk factors. Peripheral vascular disease was uncommon because they are focusing on arterial disease, something that would not be a commoon association with MS because of the ages of the patients.

in other words, this paper has nothing to do with ccsvi
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Nothing to do with CCSVI

Postby MarkW » Sat Apr 03, 2010 3:20 am

Nothing to do with CCSVI, I agree fully.

Having treated any CCSVI symptoms pwMS have (venoplasty and/or stents) then also watch for other vascular symptoms. There are plenty of well used medicines available to treat the symptoms mentioned in the paper.

Kind regards,
MarkW
Mark Walker - Oxfordshire, England. Registered Pharmacist (UK). 11 years of study around MS.
Mark's CCSVI Report 7-Mar-11:
http://www.telegraph.co.uk/health/8359854/MS-experts-in-Britain-have-to-open-their-minds.html
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Postby Billmeik » Sat Apr 03, 2010 8:15 am

this is a big topic since buffalo. And one or two of the new articles from ang int find a strong correlation between level of severity of ccsvi and ms.

So is the ms causing the ccsvi? You can see a model where scar tissue builds up in the veins over time, perhaps because so much scar tissue is getting washed down from the ms lesions...


The two points in favour of the ccsvi causing the ms are Putnam who in 1936 blocked the cs veins in dogs and created encephalomyelitis, which is kind of ms. The other is restenosis. When veins closing back up causes MS attacks its good news for this side of the arguement.

so if the latter is true is progression coming from the ccsvi? I think there are medical precedents from varicose veins in the legs etc. where veinous things progress and build up tissue.
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Postby Cece » Sat Apr 03, 2010 5:33 pm

Billmeik wrote:so if the latter is true is progression coming from the ccsvi?


I don't see a way for this to be answered except through a study that follows people over time.

And hopefully any people being studied opt out and go get treated for CCSVI!!
"However, the truth in science ultimately emerges, although sometimes it takes a very long time," Arthur Silverstein, Autoimmunity: A History of the Early Struggle for Recognition
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ms- ccsvi

Postby Dovechick » Mon Apr 05, 2010 7:10 am

From my reading of material and papers so far on CCSVI it appears that constrictions have nothing to do with plaques, but more to do with congenital malformations, pressures on the veins by bones or tissue, sometimes caused by compressure due to injury.
Maybe medical people will know different...
Michele,  warrior4MS, mother and champion for Ella, the MSer. The solution is out there we just have to ask the right questions.
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