Letter to Dr. Zamboni from Dr. Tudor Mihaita

A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.

Letter to Dr. Zamboni from Dr. Tudor Mihaita

Postby happy_canuck » Tue Apr 06, 2010 2:32 pm


Here's the text:

Professor P. Zamboni,

From the two articles(“Intracranial Venous Haemodynamics in Multiple Sclerosis” and “Chronic cerebrospinal venous insufficiency in patients with multiple sclerosis”) I found out about the idea that you support concerning multiple sclerosis. With your permission, I would like to lead this discussion on another track.

Very recently, in the summer of 2009,at the Congress in Prague "Controversies in Neurology" 8-11 October 2009, someone comes up with the idea of unifying theories about inflammation in general ( "The 'Continuum' of a unified theory of diseases" - G. Vithoulkas -- University of the Aegean, Mytilene, Greece). It's an observation of great common sense. But the concretization is missing. In this sense comes my attempt to explain this, with direct application of what is happening in the particular case of multiple sclerosis.I had some previous communication attempts on inflammation but received no reply.

You will wonder perhaps when I begin to invoke some strange disease that are not too often recognized by medicine today. The first is Castleman's disease, a pre-lymphoma which has a lot of inflammation and is very heterogeneous in its manifestations, pathological, clinical and evolutionary. In this disease there is the phenomenon of "bulge in the vein" (http://www.castlemans.org/about) that I cite as the cause of the venous stenosis that you identified. An evolutionary and slow phenomenon, presumably present also at young age, since the literature abounds in communication about Castleman disease, a localized form in children. Maybe the stenosis of large veins (jugular and azygos vein) is one of the unknown localizations of the disease. As for evolution, I do not understand, for example why your case, Augusto Zeppi 40 years from Ferrara, required a second intervention in a year because of the restenosis from one of jugular veins.

Another phenomenon that baffles almost all clinical medicine today is the identification, in the early 90s, of micro-vesicle (MVS), micro-particles (MPs) and exosomes, in almost all diseases (atherosclerosis, cancer, multiple sclerosis, collagenosis etc..). Never was medicine so disconcerted as when faced with this phenomenon. As time passes, these MVS, MPs and exosomes seem to be something alien to the human body. The explanation that they are oxidative modified lipoproteins ( only in case of the atherosclerosis) is clearly false.
A third situation that i bring into discussion is an infectious disease called melioidosis, with its gram negative bacterial agent - Burkholderia pseudomallei, a germ that eschews identification with current bacteriological methods, so that it came to be called also ... "Stealth organism”
Before I carry forth with, in my opinion, demystifying the three cases raised above, two sentences from the DISCUSSION section of your paper "Intracranial venous Haemodynamics in Multiple Sclerosis" namely: "It has been established that steady laminar shear stress promotes the release of factors from endothelial cells that inhibit coagulation and migration of leukocytes, while simultaneously promoting normal endothelial cell function "(Bergan et. al., 2006, Sorescu et. al., 2004) as:" It has been established that chronic venous reflux is MLSP capable to further activated either in the vein wall or in the surrounding tissue (Sansilvestri et. al., 2007, Bergan et. al., 2006), determining an imbalance of extracellular matrix production / degradation " I remember like an echo, all I read about MVS, MPs and exosomes .In this way I found out astounded that endothelial dysfunction is invoked in atherosclerosis,in cancer and in multiple sclerosis with exosomes release and cell apoptosis.

And now the promised demystification (in my opinion).

Castleman's disease (a peculiarity, actually) as it is described up to the present time, is only ... "a tip of the iceberg" of a chronic pre-larval parasitosis with the Corti Mezocestoides Cestoda,a cestoda that does not have the whole biological cycle, fully explained up to this date. All that is strange concerning cellularity in Castleman’s disease is represented by the proligerus capsules of the Cestoda that ... release specific metascolex. In fact, hidatic sand which in the stage of protoscolecx interferes with... MVS, MPs and exosomes. It seems shocking but this situation is suitable, in my opinion, to explain something simple and natural, namely that the pre-larval Cestoda is parasited by the above mentioned bacteria - Burkholderia pseudomallei (B. P.). Based on the evidence of medical literature, B. P. is already proven to do this (intracellular parasite) in amoeba Acanthamoeba and fungus Gigaspora decipiens. From where ... it escapes! It is also very likely to have a transmissibility of a prionic type, a mechanism often invoked in connection with MVS, MPs and exosomes. In the case of multiple sclerosis, in which you have identified vein stenosis, it is likely to escape gradually, in relation to the prolongation of the circulation time of venous flow.
Another feature of B. p. is to cause hemorrhage and necrosis in acute lesions, causing ... "Iron buildup" also described and identified today by Prof. Mark Haacke (Detroit and Hamilton). In multiple sclerosis, this explosion factor that is B. P., explains the high variability of clinical forms, beginning with what is even stranger and more dramatic - fulminating forms, supra-acute (Neuromyelitis optica, acute disseminated encephalomyelitis, acute hemorrhagic leukoencephalitis - A.H.L) in which the feeling of the action of an infectious factor is very strong, yet unproven. Why, for example, in A.H.L. acute vasculitis with unidentified infectious agent interests the walls of capillary veins with necrosis and perivenous demyelinization? In these forms the situation is probably decided by the bacterial virulence and not by other factors. In the same sense, aims the article :” Association of demylinating lesions in the spinal cord and disc disease” (M. Quigg, A. Lugo, B Greenberg - Journal of Neurology volume 255 suplement 2-June 2008) which puts out the customs of classical neurology: „Pathologically, a herniated disc could impair venous outflow, at the level of the epidural venous plexus, thus creating an inviting environment for immune cells to cross the blood brain barrier. Based on this theory, herniated discs do not cause lessions, but rather create appropiate environments for their creation in individuals with autoimmune predispositions”. I don’t think we are speaking about “appropriate environments” but more likely of a bacterial agent which is present medullary and in the cartilaginous structures; melioidosis being by excellence yet another disease with musculoskeletal tropism.

I support the fact that the bacteria B. P. is a candidate and actual factor in explaining inflammation in all medicine today, as the article listed in the beginning tries to achieve with the unification of all the diseases. It is, if you will the middle ground between explaining multiple sclerosis only through inflammation or only through vascular disorder, as you have already demonstrated.

Is the epistemolog, Thomas S. Kuhn, right with the paradigmatic pattern of development in science?

In order not to waken endless discussions about "possible and impossible", I mention that the proximity to the city of Ferrara of the city Bologna, where some of your colleagues operate, raised the question: „Che cosa succede a Bologna?”.„In this context, the recent report on the isolation of B. pseudomallei in 7% of tested water resources in Bologna, northern Italy is a disquieting fact”.

http://www.phidias.us/phinfo/topicSearc ... pathogenID[]=5

PS: If you manifest the interest, I could send you my other attempts, in the form of „Letter to the Editor” ,which were turned down by a publication the previous year.

Respectfully yours,

Tudor Mihaita M.D.
Departament of neurology
Departamental Hospital
Alexandria City
National CCSVI Society: <strong><br /><a href="http://tinyurl.com/44znbct">http://tinyurl.com/44znbct</a> ~Website<br /><a href="http://tinyurl.com/3wzmkmg">http://tinyurl.com/3wzmkmg</a> ~Facebook</strong><br />
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Postby Johnson » Tue Apr 06, 2010 7:25 pm

Nice find, Sandra. I have long been saying that I think MS is caused by a parasite or bacterium. My prime suspect has always been amoebic dysentery, a water-borne disease. Of course, I am not a medico, so there you go...
My name is not really Johnson. MSed up since 1993
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transgenic DNA in GM crops

Postby Ruthless67 » Tue Apr 06, 2010 7:52 pm

If the two articles from bohemian bill on another thread have started your head spinning, then watch the Food Inc. documentary on PBS, April 14th then look into what Monsanto has been doing over the last decade or so. That should really get you spinning like a top!

Then to ramp it up to hurricane spinning look into the link between Genetically Modified foods and disease, especially Morgellons.

Soy, Corn, Wheat, Cotton, Sugar Beets, Candy, Breakfast Cereal – What You NEED to Know - dated September 14, 2008, Evelyn Vincent

Evelyn Vincent said, “I honestly cannot believe that ‘if” people knew what Monsanto and other large corporations have been doing that they would continue to buy food, or any product, that has been ‘Genetically Engineered’”.

These products should come with warnings, just like big pharma advertises their drugs: eating this food or using this product may cause breast cancer, prostrate cancer, cause you to drop dead of a heart failure at 16 years of age, cause your daughters to begin puberty at the tender age of 6, will absolutely cause the PCB levels in your body to elevate into the thousands (the acceptable world limit is 2 PPB), will cover the entire earth and waterways with high levels of PCB’s, will kill fish, frogs/toad’s, will kill our pollinators such as Honey Bee’s and butterflies, will cause you to have long-term illnesses that will cost you more money than you have for meds.

Morgellons: Biotechnology Gone Awry or Simple Psychosis?

The findings of Vitaly Citovsky, a plant biologist whose lab showed that Agrobacterium, bacteria that utilizes horizontal gene transfers to cause tumors in plants and is a key factor in genetic engineering, could transform organisms by transfer of DNA, including human cells. He was contacted by the MRF to investigate the potential presence of the Agrobacterium in Morgellons patient's biopsies. His control included healthy donor samples as well as those from the patients. Only those with Morgellons tested positive. He put out a statement on his involvement in the research in which he says that these findings do not prove that Agrobacterium causes Morgellons nor that it is in fact, an infectious disease; only that the results indicate the need for further research.
Transgenic crops and horizontal gene transfer have been seriously debated topics with the emergence of more and more genetically engineered food. Dr. Mae-Wan Ho, Director of the Institute of Science in Society, has studied this in depth, and has made frequent representations to the government on the topic. Her concerns are over the spread of transgenic DNA. Due to DNA being present in all environments, and the fact that cells can take up free DNA, it is not just the cross pollination of crops that is worrisome, but the transfer to unrelated species as well.
She also states that "horizontal gene transfer is one of the most serious, if not the most serious hazard of transgenic technology". She has been bringing this to regulator's attention since 1996, when she says there was "already sufficient evidence to suggest that transgenic DNA in GM crops and products can spread by being taken up directly by viruses and bacteria as well as plant and animal cells". 7. Ho, Dr. Mae-Wan . "Recent Evidence Confirms Risks of Horizontal Gene Transfer". Institute of Science in Society. April 3, 2008 (http://www.i-sis.org.uk/FSAopenmeeting.php). What is a main transfer source for this DNA? Agrobacterium tumefaciens, the same bacteria as those found in the Morgellons patients.

When I personally e-mailed Vitaly Citovsky, on On Mar 19, 2010, this is the reply I received,

“We are no longer researching Morgellons. Sorry, I do not think you can find any reliable info easily.”
Vitaly Citovsky
Department of Biochemistry and Cell Biology
State University of New York
Stony Brook, NY 11794-5215
Tel.: 631.632.9534
Fax: 631.632.8575
E-mail: vitaly.citovsky@stonybrook.edu

And in a later clarification article Vitaly stated that, The link between Morgellons And GM foods should be investigated further. But that funding for further research is currently non-existent at this time.

So we are not only being lied to and poisoned by the pharmaceutical companies, but our food sources are poisoning us as well. So is it any wonder we are finding Congenital Malformation??????????????

This is my warped and round about way of linking CCSVI and auto-immune diseases into all this madness. This is my personal morning rant. I am now exposed and vulnerable, to pop shots, but geeze, I get so aggravated when I feel I’m being deceived or taken advantage of or manipulated without my knowing it. That's one of the reasons I now no longer inject myself with Avonex!!! I believe for me, it's suicidal to compromise my ammune system!!!!!!!!

Could all these be the same or related? Candida albicans, Mogellons, Transgenic DNA, misc. and opportunistic fungus, castlemans????????

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Postby suze » Tue Apr 06, 2010 10:41 pm

I would really like to understand the letter by Dr Tudor Mihaita but I need someone who understands medical lingo to paraphrase it into language that I can understand.
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Re: Letter to Dr. Zamboni from Dr. Tudor Mihaita

Postby costumenastional » Wed Apr 07, 2010 4:31 am

If i got this right, he is saying that our veins become malformed (and thus we experience what Zamboni says) because of a bacteria. So, by restoring blood flow, one should get relief from MS, but the veins endothelium should continue to get damaged.
I suppose this could be a reason from the "restenosis" perspective of view. But it surely doesnt explain why Zamboni finds problem mainly to IJVs and the Azygos.

I am afraid he might be right though, since as CCSVI is being more and more researched other vascular problems are being found.

I think his point of view is very interesting. Any more thoughts?
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Postby shye » Wed Apr 07, 2010 4:50 pm

Yes, very interesting stuff here. I guess one way to pursue further inquery is to search B P bacterium, and find places where info accumulated connects to the theories here.
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