I should have called this thread ITS NOT JUST PLUMBING!
Per the newest studies they have determines that Collagen type I changes to Collagen Type III in pwMS/CCSVI.
They said this is the opposite of that found in normals.
Could Endothelin1 be the culprit?
Since Endothelin1 production is triggered by changes in sheer stress, hypoxia and hypoglcemia ( and pwMS have E1 levels higher than normal and they don't know why)
I believe the CCSVI condition triggers the endothelium to try to fix itself- it increases E1 because it is being told by signals that the vessel needs to be reinforced- E1 is as potent as a drug!
Then the high E1 level chronically could be the reason the Collagen Type I changes over time and is "remodeled" into Collagen Type III ! E1 causes fibrotic changes and hypertrophy !
there is a relationship between these vessel wall signalers.
The body works with a series of polypeptide and protein signals and responses- the aim is always homeostasis- the body likes balance and it tries to repair itself........
Just like scar is wonderful in that we heal, its never the same as normal non-scar tissue and can become bad when its adhesions or keloids.
What we need to take away from this is: Veins ( and arteries) are not merely plumbing and conduits, every square inch and there are hundreds of miles of endothelium is an organ- an organ that responses and changes,
CCSVI is not merely blocked vessels......... there is much much more.
And following an endothelial healthy lifestyle post CCSVI is imperitive.
No smoking, a healthy diet and regular exercise are very important to recover maximally from Venoplasty.
PRE-CCSVI do a few things:
Stop Smoking and anything else that may cause vaso constriction such as drinking high levels of caffiene.
Plan an exercise program, use a Physical Therapist if needed, remember any movement is exercise, and start moving if you can.
Learn about a good endothelial healthy diet and change small things with the aim to change over time. Throw out foods that are bad for you.
Stay hydrated all of the time.
Get Dr Cooke's Book " The Cardiovascular Cure" its very cheap on amazon.