bluesky63 wrote:Cheer, I just got chills reading your reply and thinking about the idea that the vascular system could be the organ linking autoimmunity -- genetic or acquired.
astro wrote:Great discussion. I'm heading to my neuro check-up next week, and he'll probably order some bloodwork. What test(s) should I suggest he add to get more insight into Collagen/Endothelin angle?
OBJECTIVE: We tested the hypothesis that the plasma level of endothelin-1 (ET-1) is increased in patients with multiple sclerosis (MS). The peptide ET-1 is one of the most potent known vasoconstrictors. An increased level of endothelin could explain some of the vascular symptoms of these patients.
MATERIALS AND METHODS: A specific radioimmunoassay was used to determine ET-1 plasma levels. Twenty patients with MS were compared to 20 age- and sex-pair-matched healthy subjects.
RESULTS: The plasma ET-1 levels were, on average, 224% higher in the patients with MS than in the controls (p < 0.005). The mean ET-1 levels (mean +/- standard deviation [SD]) were 3.5 +/- 0.83 pg/mL (min 2.13, max 5.37 pg/mL) in patients with MS and 1.56 +/- 0.3 pg/mL (min 0.9, max 2.13 pg/mL) in healthy volunteers. Neither the different forms nor stages of MS had an influence on the results. The ET-1 level was also not correlated with the duration of the disease.
CONCLUSIONS: The plasma ET-1 level is markedly and significantly increased in patients with MS. Neither the cause of such an increase nor the pathogenetic role is known.
PCakes wrote:Dear Joan,
Please post your 'endothelial dysfunction home game' over here on TiMS.. good reminders c/w a smile. Win win.
I tried to copy and paste one of the ppt slides into this, but wasn't able to.
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