Ok, this is going to be a rambler. Chlamydia Pneumonia just keep coming up in my research into MS. As a matter of fact, following the breadcrumbs of research is how I ended up at Tim’s back in 2009.
The article below states that CP is responsible for the macrophages’ cell walls becoming immobile, they accumulate in the blood vessel walls, setting the stage for atherosclerosis.
(hardening of the arteries)
So………..is there a connection here? Are we the hosts for the viruses/fungi’s that, as parasites, are over time, the cause of these shifts & changes in our veins.
My oldest brother was born with a fugal growth on his feet that took over 14 years to diagnosis that turned out to be a Staphylococcus infection. When I was born, I was diagnosed with severe eczema. Was my mom the carrier? Did we get these parasites in vitro? Do they manifest differently from individual to individual even in a family?
Re: Collagen shifts in vein walls found in CCSVI
Quote from Cheerleader
“Also wanted to restate what Dr. Dake said about Jeff's veins that has stayed with me...he said he'd never seen anything like them before, that they seemed "sticky". I think this vascular wall remodeling and potential collagen shift may be a very important part of the equation. And addressing endothelial dysfunction and NO may be part of the solution.”
Could Jeff’s sticky walls have been macrophage that were made rigid and unable to move? Is it similar or related to the collagen shift? Could taking Echinacoside/Echinacea help?
Chlamydia pneumonia Responsible for Atherosclerosis
Posted on August 22, 2012
Chlamydia also are intracellular pathogens, meaning that they can only grow and reproduce inside of another cell.
One of the keys lies in the macrophages’ cell walls, which store cholesterol and usually tightly control it.
But when it’s infected with C. pneumoniae, the microbe traffics cholesterol from the macrophage cell membrane to its own, causing a change in the macrophage that makes it rigid and unable to move.
The bacterium also disturbs the macrophage’s production of toxins in a process that transforms them into “signaling molecules,” which support functions that keep the bacterium alive.
“C. pneumoniae really wants to hijack the cell functions for its own use, like a parasite would,” he says. “The macrophage, though, wants to kill Chlamydia, but its killing ability has been converted to signaling.”
This is the reason the infection becomes chronic, Azenabor says. “Because of signaling, everything else in the human cell is still fine except for the altered toxins, so the bacteria can reproduce in a short time.”
As the macrophages become immobile, they accumulate in the blood vessel walls, setting the stage for atherosclerosis.
Infection and pregnancy
How is Chlamydia trachomatis, the species that causes a sexually transmitted disease, involved in the occurrence of spontaneous abortions or miscarriages?
Trophoblasts act like macrophages in many ways, and their functions are mediated by the hormones estrogen and progesterone. And cholesterol is the molecule used to produce those hormones.
Azenabor’s research shows that, like its cousin, C. trachomatis does take cholesterol from the trophoblast, and it also reproduces once inside the cell.
“It’s the same old story,” says Azenabor. “Only this time the attacked cell is a trophoblast instead of a macrophage, and the depleted cholesterol hinders production of estrogen and progesterone instead of altering toxin production.”http://www.naturalhealthschool.com/echinacea.html#2
Polyphenols found in Echinacea were found to protect collagen from free radical damage.
The SDS-PAGE pattern of native collagen is markedly modified by free radical attack, with formation of a great number of peptide fragments with molecular masses below 97 kDa: in the presence of microM concentrations of echinacoside, there is a complete recovery of the native profile. Collagen degradation was, in fact, dose-dependently inhibited by all the compounds, with the following order of potency: echinacoside approximately chicoric acid > cynarine approximately caffeic acid > chlorogenic acid, with IC50 ranging from 15 to 90 microM. These results indicate that this representative class of polyphenols of Echinacea species protects collagen from free radical damage through a scavenging effect on reactive oxygen species
Echinacoside is a natural phenol. It is a caffeic acid glycoside from the phenylpropanoid class. It is constituted from a trisaccharide consisting of one glucose and two rhamnose moieties glycosidically linked to one caffeic acid and one dihydroxyphenylethanol (hydroxytyrosol) residue at the centrally situated rhamnose. This water-soluble glycoside is a distinctive secondary metabolite of Echinacea angustifolia and Echinacea pallida (to about 1%) but only occurs in trace amounts in Echinacea purpurea. It is also isolated from Cistanche spp.
It was first isolated by Stoll et al. in 1950 from the roots of Echinacea angustifolia. It shows weak antibiotic activity in vitro against Staphylococcus aureus and Streptococci.http://en.wikipedia.org/wiki/Eczema
- Eczema has increased dramatically in England as a study showed a 42% rise in diagnosis of the condition between 2001 and 2005, by which time it was estimated to affect 5.7 million adults and children. A paper in the Journal of the Royal Society of Medicine says Eczema is thought to be a trigger for other allergic conditions. GP records show over 9 million patients were used by researchers to assess how many people have the skin disorder.