This Is MS Multiple Sclerosis Community: Knowledge & Support

Ruth, dont forget the gene mutation that might be playing a role. It takes generation of mutations to result in bad genes. So for generations we might be getting mutated genes. And we will pass on these bad genes to our children ...

Ruthless,

it's interesting you point out


When studying the incidence of MS in the Faroe Islands after WWII, John F. Kurtzke speculated that an infectious agent with an incubation time of approximately 7.2 years may play a role in the development of MS:

http://www.stanford.edu/~siegelr/rnorris.html

Now the usual suspects (especially that Colin Rose) will pick up spelling mistakes in the report to bash it, as if there is a direct co-relation between spelling & intellectual ability.

...and how many other languages would "he who shall not be named" speak, anyway? I cannot make out one character of the Arabic language... I put no stock in anything that man vomits into cyberspace...

Changes to the endothelial lining of the blood vessels can happen in months ...doesn't take a generation for our veins and arteries to narrow. We see this in Crp levels of inflammation--which are now occurring in healthy people.

Remember, nitric oxide disruption creates vasoconstriction and inflammation- and disrupts the blood brain barrier-- here is the mechanism in stroke--



http://stroke.ahajournals.org/cgi/conte ... /40/4/1458

I think the answers will come when we start looking at CCSVI as a chronic venous micro- stroke--

-and what changes nitric oxide distribution and creates endothelial disruption, raising Crp levels? Viruses (EBV), bacteria (cpn), low vitamin D, saturated fats, heavy metals (mercury), oxidative stress (low amounts of antioxidants from fruits and veg), Diesel fuel exhaust, pcbs in plastics, smoking (which makes MS worse, even though it dampens the immune system)....the list of nitric oxide disrupters is a veritable laundry list of modern, industrialized living. Which is what has happened to Kuwait.
cheer

_________________
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
dual stents placed 5/09
CCSVI in MS

Cheer, are you a teacher by any chance? because, every time we digress, you beat us back onto track.

BTW, just wanted to know if you are accepting any donations for CCSVI Alliance?

My late father taught public school music for 40 years, my Mom is a retired high school English teacher, but I'm just a no-good chick singer
I just think the pieces are starting to fit together, and it's exciting to me. Maybe I need to get out more?

The CCSVI Alliance is accepting donations...although we haven't launched officially, -contact the treasurer at http://www.ccsvi.org/
cheer

_________________
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
dual stents placed 5/09
CCSVI in MS

NO NO!!!!
Dont!!!!



Nice weekend to all of us.

But it makes me wonder what those disruptors may have been in pre-modern, pre-industrial times. Think Halldora circa 1000 AD, Creuvhalier in the 1860s, etc. I think that the pathogenesis is more mundane, but the exacerbating factors more varied - can't point to smoking, Epstein-Barr in non-smokers, or in those negative for EB. Smoking and EB are disparate suspects to boot.

So, MS/CCSVI has been around for a very long time, but seems to be picking up in prevalence. Kuwait is interesting because of the marked increase since Gulf War I (17 years is a short window for "natural" mutations). Thinking of genetic mutation, what could cause such a rapid mutation in Kuwait? Depleted uranium? Anthrax vaccines?

Bah! I may know how to spell, but my intellect is definitely suffering - I forget where I was, and where I was trying to get too. My three year old is not helping me to concentrate.

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My name is not really Johnson. MSed up since 1993

As everyday those medical sources are helping me rebuilt my cheesy brain! I feel so bless... to be a part of what you are diong here;)

Love you all!
have a nice and cool weekend;)

Wow....I think we may have a partial answer as to the rising MS rates in Kuwait. They've been "super sized"----



In the venous paradigm of MS, saturated fats, lack of vitamin D, lack of exercise and obesity are vasoconstrictors and endothelial disrupters....could certainly make MS worse (as well as other autoimmune disorders) This is so sad...our global community needs to deal with this epidemic.
link to article

cheer

_________________
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
dual stents placed 5/09
CCSVI in MS

There are numerous studies which indicate a link between obesity and CVI, for example: http://www.schattauer.de/en/magazine/su ... /show.html

Now why should this only affect the legs?

Then again, this would be a contradiction to the theory that CCSVI is congenital. But there are so many different signs of CCSVI... so the assumption that there are different reasons for venous obstructions all leading to CCSVI makes sense.

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"There is only one good, knowledge, and one evil, ignorance." Socrates

Cah-
Thanks for the CVI/obesity links...
I believe you can have a congenital venous malformation, and environmental/lifestyle factors will make stenosis and reflux even worse....just as you can have a genetic predisposition to high cholesterol or stroke. These malformations may start out "baby sized" and grow, due to vasoconstriction and endothelial disruption. This may be why we are seeing higher rates of, not only MS, but all autoimmune diseases.
cheer

_________________
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
dual stents placed 5/09
CCSVI in MS

What is there is simply no increase in real incidence but in reported incidence? Some years ago there was no possible diagnosis before death, and at that time it really didn't matter. What if we are only seeing an advance in diagnosis?

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You can get a worldwide list of available sites for CCSVI at http://www.ccsviclinic.info

Possible...but this has happened VERY quickly (in the last 10 years) and there was diagnosis in place in Kuwait, as evidenced by the published research.
cheer

_________________
Husband dx RRMS 3/07
dx dual jugular vein stenosis (CCSVI) 4/09
dual stents placed 5/09
CCSVI in MS

That's intriguing! If it was only a question of lifestyle, the main age of MS onset was contradictory to that. MS would be seen much more in older patients, as in other "livestyle" diseases like stroke or diabetes. So the congenital factor must be strong. But if it was only the congenital issue, the average MS onset would be earlier. But with some sort of interference of both, it fits perfectly. That is, at least to my laypersons mind...

_________________
"There is only one good, knowledge, and one evil, ignorance." Socrates