Restenosis Is A Natural Control

A forum to discuss Chronic Cerebrospinal Venous Insufficiency and its relationship to Multiple Sclerosis.

Restenosis Is A Natural Control

Postby NoDrainer » Mon Apr 26, 2010 10:39 am

Brilliant insight by Frodo:

"Restenosis is a natural control. Angioplasty trials can use the restenosis cases like controls and a controlled human trial is always more reliable than an animal model."

The on-off switch for venous insufficiency. It's a no drainer.
User avatar
NoDrainer
Getting to Know You...
 
Posts: 14
Joined: Thu Jan 21, 2010 4:00 pm

Advertisement

Postby Cece » Mon Apr 26, 2010 11:12 am

I think you and Frodo are right...particularly if the determination of restenosis is done blindly or double-blindly...otherwise you have the risk of not being able to trust that the determination of restenosis isn't influenced by the fact that the person has relapsed.

Honestly none of this should be hard to prove or disprove.

I know research cannot be instantaneous, but to whatever extent that this is not fast-tracked, there are people whose lives are going to be affected forever...if whatever relapse or steady decline comes as we wait...it's tragedy in the midst of joyous discovery.
"However, the truth in science ultimately emerges, although sometimes it takes a very long time," Arthur Silverstein, Autoimmunity: A History of the Early Struggle for Recognition
Cece
Family Elder
 
Posts: 9024
Joined: Mon Jan 04, 2010 4:00 pm

Postby LR1234 » Mon Apr 26, 2010 11:54 am

Thats what Dr Simka is doing I think. After my procedure I contacted him as I thought I might have some issues again and he wrote me down as a "control" visit.
LR1234
Family Elder
 
Posts: 1505
Joined: Wed Feb 11, 2009 4:00 pm
Location: California

Postby frodo » Mon Apr 26, 2010 12:48 pm

LR1234 wrote:Thats what Dr Simka is doing I think. After my procedure I contacted him as I thought I might have some issues again and he wrote me down as a "control" visit.


I think in this case he just means that he is controlling you. As far as I know he has never shaped his procedures as a clinical trial.

But there are doctors reading this forum that could conduct clinical trials. Let's hope that one of them thinks the idea is worth trying, though it is not clear how the medical community will consider this special controls.

By the way, thanks NoDrainer for posting it as a separate thread.
User avatar
frodo
Family Elder
 
Posts: 617
Joined: Wed Dec 02, 2009 4:00 pm

Postby NoDrainer » Mon Apr 26, 2010 1:44 pm

Cece: Yes, a steady humiliating decline via chronic venous stroke!!!

Frodo: A make-my-week magic moment of clarity there pawdner!
User avatar
NoDrainer
Getting to Know You...
 
Posts: 14
Joined: Thu Jan 21, 2010 4:00 pm

Postby NoDrainer » Mon Apr 26, 2010 3:33 pm

edited: incorrect info.
Last edited by NoDrainer on Tue Apr 27, 2010 9:23 am, edited 1 time in total.
User avatar
NoDrainer
Getting to Know You...
 
Posts: 14
Joined: Thu Jan 21, 2010 4:00 pm

Postby se1956 » Tue Apr 27, 2010 1:08 am

An example:

1st step: All get ballooning
2nd step: Every patient calculates his MSIS value every week
3rd step: Control checkup every 3 months (doppler/MRV?)

The patient doesn't know the results of the controls and the physician doesn't get the MSIS-values.

4th step: After 12 month, on unblinding, there should be a (time delayed) (cross)correlation between the MSIS values and the occurrence of restenosis.

R.
User avatar
se1956
Family Member
 
Posts: 65
Joined: Wed Dec 02, 2009 4:00 pm

Postby TFau » Tue Apr 27, 2010 1:27 pm

I think this is a brilliant idea! Has someone brought it up with Dr. Scalfani - since we seem to have his ear? I haven't checked that thread in a while.
User avatar
TFau
Family Elder
 
Posts: 222
Joined: Tue Nov 24, 2009 4:00 pm

Postby frodo » Wed Apr 28, 2010 6:52 am

TFau wrote:I think this is a brilliant idea! Has someone brought it up with Dr. Scalfani - since we seem to have his ear? I haven't checked that thread in a while.


I haven't. And as far as I know nobody has.
But his thread looks quite busy. If we post it now maybe he will not read it.
Maybe we can post it in his thread when questions calm down a little bit.
User avatar
frodo
Family Elder
 
Posts: 617
Joined: Wed Dec 02, 2009 4:00 pm

Postby frodo » Thu Apr 29, 2010 2:45 am

frodo wrote:
TFau wrote:I think this is a brilliant idea! Has someone brought it up with Dr. Scalfani - since we seem to have his ear? I haven't checked that thread in a while.


I will post it now. It seems that last messages for Dr. Scalfani are just thanking messages.
User avatar
frodo
Family Elder
 
Posts: 617
Joined: Wed Dec 02, 2009 4:00 pm

Postby mlrm » Thu Apr 29, 2010 2:58 am

Hi you guys:-)

I think that model looks great. In fact that is what those of us that need more than one procedure is already doing! There is no other choise for us than to go back again and get more checkups!

I'm from Denmark and am now planning to go to the 3rd country on my list to have the procedure done for the 2nd time. But first I had to make a stop in New York and Germany. My God I really get to see the world!

Read my website to hear my story:

http://www.123hjemmeside.dk/flowoflife

Marie Louise
User avatar
mlrm
Getting to Know You...
 
Posts: 10
Joined: Wed Dec 16, 2009 4:00 pm

Postby Billmeik » Thu Apr 29, 2010 6:17 am

ok so patients are frustrated because we are getting damaged while they look for proof. Is this where patients can help?

1.prove that restenosis occurs before an ms attack.


this seems obvious but if there was documentation on this it would be huge!
So somewhere someone has to get a doppler every day and show the veins close first before the ms.

that's all that would be enough.
User avatar
Billmeik
Family Elder
 
Posts: 694
Joined: Fri Nov 27, 2009 4:00 pm


Return to Chronic Cerebrospinal Venous Insufficiency (CCSVI)

 


  • Related topics
    Replies
    Views
    Last post

Who is online

Users browsing this forum: No registered users


Contact us | Terms of Service